NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-AT-24-014 from the NIH Guide for Grants and Contracts
Notice NOT-OD-23-185 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-23-302 from the NIH Guide for Grants and Contracts. The goal of this NOFO is to support R01 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets
Funding Opportunity PAR-23-301 from the NIH Guide for Grants and Contracts. The goal of this NOFO is to support R21 applications for novel theory and methods development that better delineate how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary across the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, simulations, and validation using available large-scale datasets
Funding Opportunity RFA-DA-24-006 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to solicit proposals for basic science experiments involving humans (BESH) aimed at elucidating neurobiological mechanisms underlying the influence of psychosocial stress on neurobehavioral function and risk for substance use disorders (SUD) and co-occurring psychiatric disorders in people living with HIV (PLWH). As referred to in NOT-OD-18-212, BESH are prospective basic science studies involving human participants that fall within the NIH definition of a clinical trial and also meet the definition of basic research. Such studies prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental processes or principles. Applicants proposing projects involving animal models or observational studies in humans should use the companion NOFO, RFA-DA-24-005. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material (https://extramural-intranet.nih.gov/sites/default/files/IC-Specific%20NOFO%20PEDP%20Inclusion%20Template%2003-28-2023.pdf ).
Funding Opportunity RFA-DA-24-005 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity is to solicit proposals for research aimed at elucidating neurocognitive and other neurobiological mechanisms underlying the influence of psychosocial stress on the risk or impact of substance use disorders (SUDs) and co-occurring psychiatric disorders in people living with HIV (PLWH).
Notice NOT-OD-23-188 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-NS-23-032 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to solicit applications for Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers. These Centers promote collaborative basic, translational, and clinical research, and provide important resources that can be used by the national muscular dystrophy research community. The Centers also provide outstanding environments for the training of new scientists electing to pursue careers conducting research in high priority areas of muscular dystrophy. Furthermore, Center investigators participate in community outreach efforts to increase awareness and convey the importance and implications of their research activities to the patient and advocacy communities.
Funding Opportunity PAR-23-309 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support novel and innovative research that examines and/or intervenes upon the underlying and multilevel causes, pathways, and factors adversely impacting the health and well-being of persons living with one or more disabilities among populations experiencing health disparities.
Funding Opportunity RFA-AI-23-054 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to support basic research that will elucidate mechanisms of Fc-mediated antibody functions, including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). Supported studies are expected to generate foundational data and tools that can be applied to the prediction of Fc-mediated killing activity by antibodies. Such data should accelerate development of therapeutic monoclonal antibodies and design of vaccines or vaccine-adjuvant combinations that induce antibody responses capable of killing infected host cells, particularly in cases where induction of neutralizing antibodies fails or is insufficient for clearance of infection
Notice NOT-OD-23-189 from the NIH Guide for Grants and Contracts
Notice NOT-OD-23-183 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-MD-24-003 from the NIH Guide for Grants and Contracts. This initiative will support multilevel and multidisciplinary intervention research to improve quality of life and promote successful aging among people with HIV with HIV associated non-AIDS comorbidities across the life course from racial and ethnic and lower socioeconomic status groups.
Funding Opportunity RFA-DA-24-066 from the NIH Guide for Grants and Contracts. The importance of prevention in combatting the opioid crisis is clear identifying and implementing effective strategies to prevent the onset of opioid misuse and use disorder and reducing the need to treat disorders yields positive individual, societal, and financial benefits. In 2020, 9.5 million people aged 12 or older misused opioids in the past year (NSDUH, 2021), suggesting that there are millions of people whose trajectories could have been changed, had they been exposed to an effective prevention strategy. Currently funded HEAL studies are testing whether existing programs shown to prevent or treat non-opioid substance use disorders might generalize to opioids. However, there remain many gaps in knowledge about how to deploy prevention services. Often effective strategies are not adopted, implemented, or scaled-up, limiting their reach and impact. There is a critical need for research to develop innovative strategies to implement and sustain prevention services that are affordable, practical, sustainable, and designed in partnership with end-users. To address these gaps, we propose an RFA with multiple receipt dates calling for investigator-initiated research that will address priorities in the dissemination and implementation of prevention services, and the creation of a prevention infrastructure.
Funding Opportunity RFA-DA-24-067 from the NIH Guide for Grants and Contracts. The importance of prevention in combatting the opioid crisis is clear identifying and implementing effective strategies to prevent the onset of opioid misuse and use disorder and reducing the need to treat disorders yields positive individual, societal, and financial benefits. In 2020, 9.5 million people aged 12 or older misused opioids in the past year (NSDUH, 2021), suggesting that there are millions of people whose trajectories could have been changed, had they been exposed to an effective prevention strategy. Currently funded HEAL studies are testing whether existing programs shown to prevent or treat non-opioid substance use disorders might generalize to opioids. However, there remain many gaps in knowledge about how to deploy prevention services. Often effective strategies are not adopted, implemented, or scaled-up, limiting their reach and impact. There is a critical need for research to develop innovative strategies to implement and sustain prevention services that are affordable, practical, sustainable, and designed in partnership with end-users. To address these gaps, we propose an RFA with multiple receipt dates calling for investigator-initiated research that will address priorities in the implementation and sustainability of prevention services, and the creation of a prevention infrastructure.
Notice NOT-MH-23-395 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-23-284 from the NIH Guide for Grants and Contracts. Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPORE). The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a highly related group of cancers. For the purpose of this FOA, a group of highly related cancers are those that are derived from the same organ system, such as gastrointestinal, neuroendocrine, head and neck, and other cancers. Other programmatically appropriate groups of cancers may include those centered around a common biological mechanism critical for promoting tumorigenesis and/or cancer progression in organ sites that belong to different organ systems. For example, a SPORE may focus on cancers caused by the same infectious agent or cancers promoted and sustained by dysregulation of a common signaling pathway. In addition, a SPORE may focus on cross-cutting themes such as pediatric cancers or cancer health disparities. The research supported through this program must be translational and must stem from research on human biology using cellular, molecular, structural, biochemical, and/or genetic experimental approaches. SPORE projects must have the goal of reaching a translational human endpoint within the project period of the grant.
Notice NOT-MH-23-390 from the NIH Guide for Grants and Contracts
Notice NOT-TR-23-027 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DA-25-017 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to: 1.Support mining of SCORCH data to identify cell types, transcripts, enhancers, or transcriptional networks that play a role in HIV/ART or SUD molecular responses 2.Support functional validation studies (e.g. epigenomic or transcriptomic manipulation, high throughput secondary screening, etc.) to confirm or deny a biological role for data-mined cell types, transcripts, enhancers, or transcriptional networks in HIV/ART or SUD molecular responses 3.Provide foundational knowledge for understanding SUD and/or HIV/ART molecular mechanisms and to generate validated targets that could serve as a foundation for new SUD or HIV therapeutics (including NeuroHIV cognitive phenotypes)