NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity PAR-23-275 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to encourage applications for research projects within the mission of either the NIAID mission or the NIDDK. This NOFO seeks to support either (a) a New Investigator (NI), an individual who has not previously competed successfully for substantial, independent funding from NIH, or (b) are an 'At-Risk' investigator, an individual who had prior support as a PD/PI on a substantial independent research award and unless successful in securing a substantial research grant award in the current fiscal year, will have no substantial research grant funding in the following fiscal year, from diverse backgrounds, including those from groups underrepresented in the health-related sciences. The purpose of this funding opportunity announcement is to encourage applications for research projects within the mission of either the NIAID or the NIDDK.
Notice NOT-NR-23-017 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AI-23-056 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for the Computational Models of Influenza Immunity Cooperative Agreement Program. The program will employ computational modeling and immunologic studies to advance our understanding of the requirements for improving anti-influenza immunity, including inducing broad immune protection and enhancing immune durability. This program will help inform design of universal or improved seasonal flu vaccines. Projects may lead to a better understanding of how pre-existing immunity and repeat exposures (natural infection and/or vaccines) shape an individuals immune landscape. Predictive modeling of adjuvants/vaccine formulations and experimental validation supported by this program should lead to enhanced host immune responses and universal or improved seasonal influenza vaccine efficacy.
Notice NOT-HL-23-106 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-RM-23-019 from the NIH Guide for Grants and Contracts. The RFA will solicit applications for the Human Virome Program under the NIH Common Fund to establish multicomponent Virome Centers that will focus on the identification and characterization of the human virome in longitudinal and diverse cohorts across several body sites and tissues. The multicore structure of each center will allow for specialized and broad expertise in isolating viruses (circulating, proviral, integrated forms) and a coordinated, and comprehensive research program for recruiting diverse participants, collecting and analyzing many types of biospecimens, standardizing and analyzing center data, and addressing ethical, social and legal implications of human virome research. The Centers will also work collaboratively across the program consortium of separately awarded investigative teams in the coordination and management of consortium policies and practices. Similar to other U54 initiatives, the virome centers have unique objectives and specific review criteria and core specifications outlined in the RFA, and currently, there are no existing study sections with the necessary expertise to review this complex program.
Funding Opportunity RFA-RM-23-018 from the NIH Guide for Grants and Contracts. This is an RFA for the NIH Common Fund Human Virome Program (HVP). The Common Fund HVP aims to extensively characterize the human virome and create tools, models, methods that will enable in-depth study of its variation in relation to host factors and its influence on health and disease. This NOFO intends to address the technological and methodological challenges that are currently hindering robust interrogation into the constituents and functionality of the human virome. It seeks application for the development of innovative and novel tools, models, and methods to overcome theses major challenges in identifying and characterizing viruses, as well as, development of computational biology and bioinformatics tools to enhance the analysis of the virome.
Funding Opportunity RFA-RM-23-017 from the NIH Guide for Grants and Contracts. This is an RFA for the NIH Common Fund Human Virome Program (HVP). The Common Fund HVP aims to extensively characterize the human virome and create tools, models, methods that will enable in-depth study of its variation in relation to host factors and its influence on health and disease. The overarching goal of this NOFO is to study interactions between the virome, human host, and microbiota. It seeks application for characterizing tissue tropism and host reservoirs for all resident viruses and to define their functional interactions within human host tissues and the microbiome.
Notice NOT-OD-23-181 from the NIH Guide for Grants and Contracts
Funding Opportunity PA-23-271 from the NIH Guide for Grants and Contracts. The purpose of this Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship to Promote Diversity in Health-Related Research award is to enhance the diversity of the health-related research workforce by supporting the research training of predoctoral students from diverse backgrounds including those from groups that are underrepresented in the biomedical, behavioral, or clinical research workforce. Through this award program, promising predoctoral students will obtain individualized, mentored research training from outstanding faculty sponsors while conducting well-defined research projects in scientific health-related fields relevant to the missions of the participating NIH Institutes and Centers. The proposed mentored research training is expected to clearly enhance the individual's potential to develop into a productive, independent research scientist. This Notice of Funding Opportunity (NOFO) does not allow candidates to propose to lead an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial, but does allow candidates to propose research experience in a clinical trial led by a sponsor or co-sponsor.
Notice NOT-CA-23-091 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AA-23-006 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) seeks to support studies that will inform safe and effective medication-assisted, psychosocial, and complementary interventions for people with co-occurring Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD). Alcohol increases lethal opioid overdose risk. As a result, treatment providers may under-prescribe or be reluctant to provide opioid agonist therapies (OATs) such as methadone and buprenorphine to people with OUD who also have AUD or misuse alcohol. There is also scant research on non-pharmacological therapies for people with OUD-AUD. Reciprocal relationships between opioid use and alcohol use has been observed for OUD-AUD patients such that reduced opioid intake may result in increased drinking which heightens opioid relapse and overdose risk and suggests an urgent need for targeted therapies in this population. Research projects dedicated to OUD treatment and prevention, while not excluding subjects who drink, seldom explicitly recruit subjects with AUD. The purpose of this NOFO is to support clinical research project development, including piloting study design and research protocols, subject recruitment, and initiating data collection and analysis pertinent to studying treatment practices for people with OUD-AUD.
Funding Opportunity RFA-AA-23-005 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) seeks to support studies that will inform safe and effective medication-assisted, psychosocial, and complementary interventions for people with co-occurring Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD). Alcohol increases lethal opioid overdose risk. As a result, treatment providers may under-prescribe or be reluctant to provide opioid agonist therapies (OATs) such as methadone and buprenorphine to people with OUD who also have AUD or misuse alcohol. There is also scant research on non-pharmacological therapies for people with OUD-AUD. Reciprocal relationships between opioid use and alcohol use has been observed for OUD-AUD patients such that reduced opioid intake may result in increased drinking which heightens opioid relapse and overdose risk and suggests an urgent need for targeted therapies in this population. Research projects dedicated to OUD treatment and prevention, while not excluding subjects who drink, seldom explicitly recruit subjects with AUD. The purpose of this NOFO is to support secondary analysis of data from relevant clinical projects and archives, and to support new hypothesis-clarifying studies to identify how people with OUD-AUD are being treated and associated treatment outcomes, identify challenges for treating people with OUD-AUD, and formulating best treatment practices for this population.
Funding Opportunity PAR-23-300 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to invite applications from research institutions in low- and middle-income countries (LMICs) to provide senior administrators from these institutions with advanced training in the management of NIH grants. The goal is to improve oversight of NIAID grant awards and compliance with NIH funding policies and Federal research funding requirements for NIAID-supported foreign institutions in LMICs.
Funding Opportunity RFA-DA-25-003 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support the continuation of NIDA's HIV Cohorts Program, encouraging existing and new sites to address new emerging and/or high priority research on multidisciplinary aspects of HIV/AIDS and substance abuse in alignment with NIH-HIV research priorities in order to inform policy or practice.
Funding Opportunity RFA-ES-23-010 from the NIH Guide for Grants and Contracts. This NOFO solicits applications for establishing a Center for Exposome Research Coordination (CERC) that will serve the broad biomedical research community by coordinating and advancing exposome research to accelerate precision environmental health. The CERC will engage existing and ongoing exposome initiatives around the globe to promote methodological advancement and best practices, provide training and education, and foster national and international collaborations.
Notice NOT-RM-23-024 from the NIH Guide for Grants and Contracts
Notice NOT-HD-23-025 from the NIH Guide for Grants and Contracts
Notice NOT-DK-23-032 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-23-285 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this FOA, Native Americans include the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. ma
Funding Opportunity PAR-23-298 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this FOA, Native Americans include the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. ma