NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-CA-19-024 from the NIH Guide for Grants and Contracts
Notice NOT-MH-19-012 from the NIH Guide for Grants and Contracts
Notice NOT-OD-19-069 from the NIH Guide for Grants and Contracts
Notice NOT-CA-19-023 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DK-18-029 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks applications for the George M. OBrien Urology Cooperative Research Centers Program (U54). This program will foster multi- and interdisciplinary collaboration between basic, translational, and clinical researchers with diverse expertise to address questions of underlying etiology and biological and clinical features of benign genitourinary conditions within the NIDDKs mission. In addition, the program will serve as a national resource for the larger urologic research community and provide opportunities for educational enrichment and engagement of investigators from urology and other, broad disciplines. All efforts will address the overall goal of improving prevention and clinical management of benign genitourinary disorders through research excellence, enhanced sharing of resources, and establishment of a robust research community.
Funding Opportunity RFA-DK-18-027 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to invite applications to support institutional career development programs in urological research that will assist MDs, PhDs, and MD/PhDs with an interest in benign urological disease or urological research to develop the skills necessary to initiate and sustain an independent research career in urological research. Research areas supported by this initiative must be related to the mission of the NIDDK (http://www2.niddk.nih.gov/Research/ScientificAreas/Urology/). This Funding Opportunity Announcement (FOA) allows appointment of Scholars proposing to serve as the lead investigator of an independent clinical trial; or proposing a separate ancillary clinical trial; or proposing to gain research experience in a clinical trial led by another investigator, as part of their research and career development.
Funding Opportunity RFA-HS-19-001 from the NIH Guide for Grants and Contracts. This R18 Request for Application (RFA) calls for the creation and utilization of Patient Safety Learning Laboratories. These learning laboratories are places and networks where transdisciplinary teams identify closely related threats to diagnostic or treatment efforts associated with a high burden of harm and cost. Following a systems engineering methodology, the learning laboratories stretch professional boundaries, envision innovative designs, and take advantage of brainstorming and rapid prototyping techniques that other leading industries employ. Promising prototypes undergo further develop-test-revise iterations, and subsequent integration as a working system. After further improvements are made to the integrated working system, its efficacy is evaluated in a realistic simulated or clinical setting
Notice NOT-HS-19-010 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-19-178 from the NIH Guide for Grants and Contracts. The Shared Instrumentation for Animal Research (SIFAR) Grant Program encourages applications from groups of NIH-funded investigators to purchase or upgrade scientific instruments necessary to carry out animal experiments in all areas of biomedical research supported by the NIH. Applicants may request clusters of commercially available instruments configured as specialized integrated systems or as series of instruments to support a thematic well-defined area of research using animals or related materials. Priority will be given to uniquely configured systems to support innovative and potentially transformative investigations. This FOA supports requests for state-of-the art commercially available technologies needed for NIH-funded research using any vertebrate and invertebrate animal species. This funding opportunity announcement (FOA) does not support requests for single instruments. At least one item of the requested instrumentation must cost at least $50,000, after all applicable discounts. No instrument in a cluster can cost less than $20,000, after all applicable discounts. There is no maximum price requirement; however, the maximum award is $750,000.
Funding Opportunity PAR-19-179 from the NIH Guide for Grants and Contracts. The Shared Instrument Grant (SIG) Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems. The minimum award is $50,000. There is no maximum price requirement; however, the maximum award is $600,000. Types of instruments supported include, but are not limited to: X-ray diffractometers, mass and nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencers, biosensors, electron and light microscopes, cell sorters, and biomedical imagers.
Funding Opportunity PAR-19-175 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for the continued support and advancement of the Mutant Mouse Resource and Research Centers (MMRRC). The MMRRC consortium is expected to facilitate research by identifying, acquiring, evaluating, characterizing, cryopreserving, and distributing mutant mouse strains to qualified biomedical investigators. A regional network of four MMRRCs and an Informatics, Coordination and Service Center (ICSC) collectively serve the needs of the biomedical research community for transgenic, knockout and other genetically-engineered mutant mice and related biomaterials. MMRRC strains are held to the highest standards to optimize reproducibility of studies and assure scientific rigor and transparency; all submitted strains are thoroughly reviewed and documented and include additional quality control measures. The Program Director/Principal Investigator (PD/PI) of each MMRRC in addition to the major resource activities is required to develop a small high risk, high return, research pilot project that complements the goals and needs of the MMRRC consortium.
Funding Opportunity RFA-AI-19-011 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications developing computational models of immunity that advance understanding of the mechanisms required to induce and/or maintain protective immunity to infectious pathogens, other than HIV, and/or vaccines against such pathogens. The main goal of this FOA is to advance development and application of computational models of immunity that are refined through iterative immunological experimentation to validate and improve the utility and robustness of the computational models. Another goal of this FOA is to make the computational models and data developed under this initiative readily available to the broader research community for further refinement or direct use in biological experimentation. This program will also support workshops and symposia to foster the use of computational models of immunity by the broader research community.
Funding Opportunity RFA-FD-19-005 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to support research to develop and qualify a Patient Reported Outcome (PRO) for Non-Cystic Fibrosis Bronchiectasis (NCFB) under FDAs Drug Development Tools Qualification Program. This would include the qualitative phase of developing the instrument, quantitative phase of testing the instrument, and qualification of the instrument. It is expected that this qualified PRO would help improve upon the current design, conduct, and interpretation of anti-infective clinical trials in NCFB patients, for which optimal endpoints are currently lacking. This work directly aligns with FDAs research area of interest to stimulate innovation in clinical evaluations and personalized medicine to improve product performance and patient outcomes."
Notice NOT-OD-19-068 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-HG-19-002 from the NIH Guide for Grants and Contracts. The National Human Genome Research Institute (NHGRI) seeks applications for the production of High Quality Human Reference Genomes (HQRG) as a component of the NHGRI Human Genome Reference Program (HGRP). One aim of the HGRP is to develop a genome reference that is representative of human population genetic diversity. To help achieve this goal, this HQRG initiative is expected to establish metrics for high quality-genome assemblies; collaborate with other HGRC awardees on sample selection and prioritization; produce on the order of 350 haplotype-resolved human genomes, using diverse samples consented for full data release; and provide capacity to help resolve error reports received by the HGRC. This and related FOA's will replace and update NHGRI's current contributions to the Genome Reference Consortium https://www.ncbi.nlm.nih.gov/.
Funding Opportunity RFA-HG-19-004 from the NIH Guide for Grants and Contracts. The National Human Genome Research Institute (NHGRI) seeks applications for a Human Genome Reference Center (HGRC). The HGRC will be the central group within a multi-component Human Genome Reference Program (HGRP) that will maintain and update the human genome reference and provide it to the scientific community. This group will also work with other HGRP members and the larger scientific community to prioritize sample choice and develop quality standards for new high-quality genome assemblies to add to the human genome reference; support state-of-the-art representations of alternate haplotypes (including representations developed by other program components); identify and respond to diverse community needs (e.g. clinical and basic) for use of the human genome reference; liaise or coordinate with other (international) resources that represent human genomic sequence and variation and/or that provide reference resources for human and other organisms. This and related FOA's will replace and update NHGRI's current contributions to the Genome Reference Consortium https://www.ncbi.nlm.nih.gov/grc
Research and Development for Genome Reference Representations (GRR) (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-HG-19-003 from the NIH Guide for Grants and Contracts. The National Human Genome Research Institute (NHGRI) seeks to support research and development for a next-generation genome reference representation. This pangenome resource will be able to capture all human genome variation and support scalable analysis in a software framework that will set a robust foundation for open science. Projects will develop improved representations for computing on the information contained within the increasing numbers of diverse genome assemblies that will make up the human reference sequence going forwards. While the high-level concept of the pangenome as a graph is well-established, further research and development is needed to refine and implement a practical representation and implementation to enable active use of population-scale variation. Software is needed that can demonstrate efficiency, scalability, computational speed, ease of use, and the ability to foster adoption of the reference and analysis tool development for a wide range of purposes. The FOA will fund multiple projects that will together help set benchmarks and standards in this domain. A primary requirement is to adhere to a high level of open science including open-source tools, standards, specifications, and robust software engineering to enable this core resource to be widely integrated in the larger community and support outside contributions. Robust design is also expected to provide a foundation for independent efforts that may have enhanced privacy and security requirements.
Funding Opportunity RFA-DK-18-028 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to seek applications for the Developmental Centers for Interdisciplinary Research in Benign Urology Program (P20). Among the goals of this Program is to further advance research in benign genitourinary diseases and disorders by building research teams and facilitating resources generation and sharing. The research teams should be composed of individuals with complementary expertise who propose to either develop innovative resources (Resource Development Projects) or a new research project (Scientific Research Projects) that utilize integrative approaches to address questions relevant to benign genitourinary diseases or disorders. While NIH defined clinical trials are not allowed, studies involving human subjects or tissues are encouraged. Resources developed by the Resource Development Projects will be shared upon validation while resources developed within the Scientific Research Projects will be shared at the end or termination of the award, as appropriate and consistent with the program goal of further advancing research. Each Developmental Center is centered on a single Project and must contain an Administrative Core and an Educational Enrichment Program. As part of the efforts of the Division of Kidney, Urologic and Hematologic Diseases (DKUH) to expand and enhance benign urology research, the Developmental Centers Program will work in partnership with the George M. O'Brien Urology Cooperative Research Centers Program (U54) and the Multidisciplinary K12 Urologic Research (KURe and UroEpi) Career Development Programs.
Funding Opportunity PAR-19-176 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) supports exploratory research projects aimed at developing cryogenic or other long-term preservation and revival approaches for Drosophila or zebrafish genetic stocks, which are essential laboratory animal models for biomedical research. The proposed project should address critical knowledge and technology gaps and describe approaches towards the development of reliable, easy-to-use and cost effective cryogenic or other long-term preservation and revival methods for wild-type and mutant strains of Drosophila or zebrafish.
Funding Opportunity PAR-19-177 from the NIH Guide for Grants and Contracts. The High-End Instrumentation (HEI) Grant Program encourages applications from groups of NIH-supported investigators to purchase or upgrade a single item of expensive, specialized, commercially available instruments or integrated systems. The minimum award is $600,001. The maximum award is $2,000,000. Types of instruments supported include, but are not limited to: X-ray diffraction systems, nuclear magnetic resonance (NMR) and mass spectrometers, DNA and protein sequencers, biosensors, electron and confocal microscopes, cell-sorters, and biomedical imagers.