NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity RFA-AA-19-006 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA), issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), encourages Research Project Grant (R01) applications proposing to conduct mechanistic studies on the relationships between sleep problems and alcohol dependence. A major impediment for recovery from alcohol use disorder (AUD) is the persistent sleep problems during abstinence promoting relapse. The objective of this FOA is to promote research in animal models and human subjects on the reciprocal relationships between chronic alcohol use and sleep disruptions. The major goal is to understand the underlying mechanisms that will lead to improved treatments for alcohol dependence. NIAAA strongly encourages collaborative efforts between experts in sleep research and established alcohol investigators to facilitate the development of proposals incorporating both areas of research.
Funding Opportunity RFA-DK-19-001 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications from institutions/organizations proposing the development of targeted mass spectrometric assays (e.g., Multiple Reaction Monitoring) for proteins and peptides of primary interest to the obesity research community (e.g., Adiponectin, Leptin, Resistin, Neuropeptide Y, Alpha-melanocyte-stimulating hormone, Peptide YY, Glucagon-like peptide 1, Ghrelin, Adrenocorticotropin, Corticotropin-releasing hormone, Gastrin, Cholecystokinin, Secretin, Vasoactive intestinal peptide, gastric-inhibitory peptide, gastrin-releasing peptide, motilin, pancreatic polypeptide,RBP4,myostatin, FGF21). The proposed assays should be highly reproducible, easily transferable to other laboratories, easy to multiplex, and validated in human plasma or serum.
Funding Opportunity RFA-DK-18-007 from the NIH Guide for Grants and Contracts. This FOA invites applications for planning cooperative agreements (U34) for a national, multisite, observational cohort study to prospectively examine the risk and protective factors for neurocognitive complications of pediatric type 1 diabetes (T1D; onset approximately ages 5-10 years) and a comparison sample. The U34 is designed to: 1) Permit early peer review of the rationale for the proposed cohort study; 2) Permit assessment of the study design; and 3) Provide support for the development of essential elements required for the design and conduct of the cohort study and the management and analysis of the study data. Consultation with NIDDK scientific staff is strongly encouraged prior to the submission of the U34 application.
Notice NOT-AA-19-005 from the NIH Guide for Grants and Contracts
Notice NOT-OD-19-047 from the NIH Guide for Grants and Contracts
Notice NOT-OD-19-062 from the NIH Guide for Grants and Contracts
Notice NOT-AT-19-020 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-19-167 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) encourages research to develop, characterize and validate innovative mammalian models that recapitulate molecular, cellular, neuropathological, behavioral and cognitive hallmarks of the Alzheimers Disease-Related Dementias (ADRD), including Lewy body dementia (LBD), vascular contributions to cognitive impairment and dementia (VCID), frontotemporal degeneration (FTD) and mixed etiology dementias (MED). Models will be expected to exhibit a broad range of features characteristic of the dementia disorder being modeled, including a mid- to late-life onset consistent with the human disorder, multiple age-dependent neuropathological processes and the associated behavioral, cognitive and/or physiological abnormalities. For each proposed mammalian model, a relevant suite of phenotypes that inform human ADRD disease progression and mechanisms should be characterized across the full life span or, for longer-living mammalian models, throughout the disease-relevant stages of adulthood. The goal of this FOA is to establish multi-dimensional mammalian models for ADRD to serve as tools to interrogate molecular disease mechanisms and identify therapeutic targets.
Notice NOT-HL-19-675 from the NIH Guide for Grants and Contracts
Notice NOT-AG-19-001 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AT-19-003 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to establish a National Center for Natural Product Technology Methodology and Performance Optimization (NP-TEMPO). This initiative is to improve upon and strengthen technologies and methods used in natural products research. The NP-TEMPO, supported through the U41 cooperative agreement funding mechanism, is expected to overcome existing research limitations by developing and/or adapting cutting edge, innovative approaches and technologies that will have significant impact on the chemical and biological annotation of natural products. This FOA is being released in conjunction with the National Center for Complementary and Integrative Health (NCCIH) NMR Open Access Data Exchange and the Office of Dietary Supplements (ODS) Botanical Dietary Supplement Research Centers Program. Collectively, the awards under these FOA constitute the NCCIH/ODS Centers Advancing Research on Botanical and Other Natural Products (CARBON) Program. Applicants applying under this NP-TEMPO FOA are encouraged to collaborate with the NODE, the Botanical Dietary Supplement Research Centers, and other NCCIH, ODS, and NIH supported grantees through NP-TEMPO Technology Demonstration Projects (TDPs).
Funding Opportunity RFA-OD-19-001 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the participating components invite applications to support Botanical Dietary Supplements Research Centers (BDSRC), which will constitute one component of the Consortium for Advancing Research on Botanicals and Other Natural Products (CARBON.2). The purpose of the BDSRC is to support collaborative, trans-disciplinary research that will contribute significantly to the optimal design of future clinical trials of the effects on human resilience of orally consumed, complex botanical products. The BDSRC are expected to focus on developing the most critical data to inform the optimal design of such future trials. Information acquired through achievement of the BDSRC specific aims is expected to allow for the design of optimally informative clinical trials, providing evidence for design decisions including, but not limited to, decisions about the appropriateness of the trial design (or of doing any trial with the product), as well as those regarding product formulations, doses, timing, eligibility criteria, participant characteristics to be collected, markers of proximal biological effect, outcome measures, etc. Products appropriate for applications responsive to the planned FOA will be limited to those for which there is rigorous, but not definitive, evidence supporting a clinically or public health significant, biologically and mechanistically plausible, and reproducible effect on, or relevant to, human biological or psychological resilience. Applications in which a purified phytochemical is the main focus will be considered unresponsive to the FOA. Applicants applying under this BDSRC FOA are encouraged to collaborate, as appropriate, with other CARBON.2 components, including the NMR Open Data Exchange (NODE) and the Center for Natural Product Technology, Methodology and Productivity Optimization (NP-TEMPO), as well as with other NCCIH, ODS, and NIH supported grantees.
Funding Opportunity RFA-AT-19-002 from the NIH Guide for Grants and Contracts. The National Center for Complementary and Integrative Health (NCCIH) with the Office of Dietary Supplements (ODS) solicit applications for the development of an NMR Open Data Exchange (NP-NODE) and associated efforts to accelerate coordination and data sharing among natural products researchers more broadly. The NP-NODE will create the resources necessary to facilitate the capacity to upload, download, store, search and analyze raw NMR data. This resource will comply with the principle that scientific data should be Findable, Accessible, Interoperable, and Reusable (FAIR). Ultimately, this resource will provide natural products researchers the power to mine NMR data in ways that are currently not possible. In parallel, the NP-NODE will develop an outreach plan to obtain input from diverse communities of researchers to develop consensus on the format and most critical features of the data repository. More broadly, the FOA supports and requires the coordination across the natural products research community to facilitate development of standards to accelerate sharing of data relevant to natural product chemistry and biology. Finally, the NP-NODE will serve an advisory function to assist NCCIH and ODS grantees in complying with the NCCIH Product Integrity Policy.
Notice NOT-AG-19-002 from the NIH Guide for Grants and Contracts
Notice NOT-OD-19-063 from the NIH Guide for Grants and Contracts
Notice NOT-AA-19-001 from the NIH Guide for Grants and Contracts
Notice NOT-AA-19-003 from the NIH Guide for Grants and Contracts
Notice NOT-AA-19-004 from the NIH Guide for Grants and Contracts
Notice NOT-HD-19-002 from the NIH Guide for Grants and Contracts
Notice NOT-OD-19-061 from the NIH Guide for Grants and Contracts