NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity RFA-NS-17-018 from the NIH Guide for Grants and Contracts. This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should address overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Budgets should be commensurate with multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.
Funding Opportunity PAR-17-063 from the NIH Guide for Grants and Contracts. As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First), the NIH invites applications to use whole genome sequencing at a Kids First-supported sequencing center. Applicants are encouraged to propose sequencing of existing pediatric cancer cohorts to elucidate the genetic contribution to childhood cancers, or to expand the range of disorders included within the Kids First Data Resource to investigate the genetic etiology of structural birth defects. These data will become part of the Gabriella Miller Kids First Pediatric Data Resource (Kids First Data Resource) for the pediatric research community.
Notice NOT-OD-17-024 from the NIH Guide for Grants and Contracts
Notice NOT-HL-16-465 from the NIH Guide for Grants and Contracts
Notice NOT-HL-16-478 from the NIH Guide for Grants and Contracts
Notice NOT-HD-16-035 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-NS-17-019 from the NIH Guide for Grants and Contracts. Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers. Projects should investigate high-impact questions in human neuroscience and disorders of the human nervous system. The research should be offered as experimental projects, or exploratory research and planning activities, for building teams, generating data and empirical results that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations.
Funding Opportunity RFA-DK-16-506 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to complete treatment of the participants recruited into the Preventing Early Renal Loss in Diabetes (PERL) Study and to analyze the outcomes of the trial. PERL is a randomized, double-blind trial to test whether the medication, allopurinol, can slow the progression of kidney disease in people with type 1 diabetes and early diabetic kidney disease.
Funding Opportunity RFA-DK-17-001 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK. The purpose of this Centers program is to bring together basic and clinical investigators as a means to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases. DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner. Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding.
Funding Opportunity PA-17-060 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to encourage research grant applications to: (1) assess and describe the current state of oral anticancer medication utilization, delivery, and adherence; (2) identify structural, systemic, and psychosocial barriers to adherence; and (3) develop models and strategies to improve safe and effective delivery of these agents so that clinical outcomes are optimized. Applications should focus research questions on at least one of the following: specific cancer type; class of drugs; and/or groups subject to disparities (e.g., elderly populations, members of low socioeconomic groups, racial/ethnic minorities). Research may be focused at the patient (pediatric, adolescent, or adult), patient-caregiver, provider, health care team, or health care delivery system level, and may include intervention studies, observational studies, or mixed-methods studies. Observational studies should emphasize modifiable risk factors for future intervention research.
Funding Opportunity PA-17-061 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to encourage exploratory/developmental research grant applications to: (1) assess and describe the current state of oral anticancer medication utilization, delivery, and adherence; (2) identify structural, systemic, and psychosocial barriers to adherence; and (3) develop models and strategies to improve safe and effective delivery of these agents so that clinical outcomes are optimized. Applications should focus research questions on at least one of the following: specific cancer type; class of drugs; and/or groups subject to disparities (e.g., elderly populations, members of low socioeconomic groups, racial/ethnic minorities). Research may be focused at the patient (pediatric, adolescent, or adult), patient-caregiver, provider, health care team, or health care delivery system level, and may include intervention studies, observational studies, or mixed-methods studies. Observational studies should emphasize modifiable risk factors for future intervention research.
Funding Opportunity RFA-AI-16-078 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications from currently funded Program Directors/Principal Investigators, Mechanistic Subcommittee members, core laboratory leaders and clinical site leaders in the "Clinical Trials in Organ Transplantation in Children (CTOT-C)" Program to support the conduct of studies of immune mechanisms using samples and clinical data collected from pediatric solid organ transplant recipients obtained in (a) ongoing or completed CTOT-C clinical studies, or (b) from other clinical trials in which the samples and data were collected with a demonstrably similar level of investigational rigor. Research supported under this FOA will focus on understanding graft dysfunction and/or loss and immune-mediated morbidity and mortality in pediatric transplant recipients. This FOA will leverage the samples and data gathered from CTOT-C's unique cohort of well-characterized patients, as well as the consortium infrastructure to carry out timely hypothesis-driven mechanistic studies. Successful ancillary mechanistic investigations will enhance the value of ongoing and completed CTOT-C projects, improve the research community's understanding of pediatric transplantation, and contribute to the identification of novel and robust surrogate endpoints for future interventional trials and/or novel therapeutic targets and biomarkers for diagnosis, treatment, and disease monitoring.
Funding Opportunity RFA-OD-17-001 from the NIH Guide for Grants and Contracts. The purpose of this FOA is for the support of a Research Resource for Human Organs and Tissues for the continued availability of human tissues and organs to biomedical researchers in the United States. The research resource is expected to facilitate procurement, preservation, and distribution of human tissues and organs to qualified biomedical researchers.
Funding Opportunity RFA-CA-16-501 from the NIH Guide for Grants and Contracts. The purpose of this limited Funding Opportunity Announcement (FOA) is to support the infrastructure to design and conduct multi-institutional Phase I and early Phase II clinical immunotherapy trials for cancer patients, using novel immunomodulatory agents. To realize these goals, the FOA will continue to support the research activities of the Cancer Immunotherapy Trials Network (CITN).
Funding Opportunity PAR-17-059 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this National Cancer Institute (NCI) R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce.
Funding Opportunity PA-17-062 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to stimulate research in promoting caregiver health using self-management. Caregiving is an important science area since the number of people living longer with chronic conditions is growing. Informal caregivers (lay caregivers) are defined as unpaid individuals (spouses, partners, family members, friends, or neighbors) involved in assisting others with activities of daily living and/or medical tasks. Formal caregivers are paid, delivering care in ones home or care settings (daycare, residential care facility). This concept focuses on informal caregivers.
Notice NOT-MH-17-006 from the NIH Guide for Grants and Contracts
Notice NOT-HL-16-476 from the NIH Guide for Grants and Contracts
Notice NOT-HS-17-004 from the NIH Guide for Grants and Contracts
Notice NOT-AG-16-082 from the NIH Guide for Grants and Contracts