NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity RFA-DA-25-053 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to develop artificial intelligence tools and experimental assays to identify new pharmacotherapeutics with lower toxicity and higher efficacy for substance use disorders (SUD) Areas of interest include but are not limited to: 1) Development of AI tools to identify potential target combinations, design new molecules, conduct virtual preclinical studies to predict efficacy and toxicity, and model in vitro and in vivo polypharmacology 2) Development of assays to assess the effects of compounds on multiple targets or functions
Funding Opportunity RFA-DA-25-054 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity is to develop artificial intelligence tools and experimental assays to identify new pharmacotherapeutics with lower toxicity and higher efficacy for substance use disorders (SUD) Areas of interest include but are not limited to: 1) Development of AI tools to identify potential target combinations, design new molecules, conduct virtual preclinical studies to predict efficacy and toxicity, and model in vitro and in vivo polypharmacology 2) Development of assays to assess the effects of compounds on multiple targets or functions
Notice NOT-OD-24-057 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-24-099 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to implement investigator-initiated clinical trials related to the research mission of the NIAID. This program provides support for hypothesis-driven, milestone-driven clinical trials. Although clinical trials not considered high-risk may be proposed, this program encourages high-risk clinical studies. High- risk does not imply human subject or patient risk, but rather defines a study that contains one or more of the following unique features: involves non-routine interventions, administration of an unlicensed product, or administration of a licensed product for an unapproved indication. Mechanistic studies are also encouraged and may be proposed under this program.
Funding Opportunity PAR-24-100 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) encourages cooperative agreement applications for implementation of investigator-initiated, high-risk clinical trials and mechanistic studies associated with high-risk clinical trials. Mechanistic work in clinical trials may be of great value because it promotes the understanding of human diseases and the development of future therapeutic modalities. Investigators are encouraged to visit the NIAID website for additional information about the research mission and high-priority research areas of the NIAID (https://www.niaid.nih.gov/research/role). Only one clinical trial may be proposed in each NIAID Clinical Trial Implementation Cooperative Agreement (U01) application
Funding Opportunity RFA-DA-25-033 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to solicit applications proposing innovative transdisciplinary research that integrates approaches across social/cognitive neuroscience and other social sciences and will lead to a testable conceptual or computational model that provides mechanistic insights into social behavior and its relationships with the onset, trajectory and impact of Substance Use Disorders (SUD) and comorbidities. This NOFO is specifically soliciting applications proposing BESH research, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research.
Funding Opportunity RFA-DA-25-032 from the NIH Guide for Grants and Contracts. The overarching goal of the supported research projects will be to determine neural and cognitive mechanisms that underlie the relationship between social cognition/behavior and the SUD trajectory.
Funding Opportunity RFA-DA-25-034 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to solicit applications proposing mechanistic transdisciplinary research in animal models that integrates approaches across social/cognitive neuroscience with perspectives from fields with complementary approaches to the study of social behavior, with the goal of developing a testable conceptual or computational model that provides mechanistic insights into social behavior and its relationships with the onset, trajectory and impact of Substance Use Disorders (SUD) and comorbidities. This NOFO is intended to support basic or translational research in non-human animal models, including secondary analysis of data from research in animal models. Applications including studies involving human subjects should submit under one of the companion NOFOs.
Notice NOT-CA-24-027 from the NIH Guide for Grants and Contracts
Notice NOT-HL-24-073 from the NIH Guide for Grants and Contracts
Notice NOT-OD-24-056 from the NIH Guide for Grants and Contracts
Notice NOT-HL-24-001 from the NIH Guide for Grants and Contracts
Notice NOT-NS-24-044 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-24-112 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support research that improves understanding of basic mechanisms and biomarkers of trained immunity (i.e., innate immune memory), plus the functional implications of trained immunity, related to 1) immune system development and function, 2) immunity to vaccines or natural infections, or 3) allergic diseases, autoimmunity, or rejection of organ/tissue/cell transplantation.
Funding Opportunity RFA-HS-24-002 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to seek applications for an Evaluation and Coordinating Center to support the AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30) (LHS E-STaR) funded under RFA-HS-23-001. The goals of the Evaluation and Coordinating Center are to facilitate coordination of activities among and between recipients; facilitate dissemination, implementation, and uptake of LHS E-STaR outputs to ensure broad public use for health system improvement; and conduct a multi-year mixed-method formative and summative evaluation of the LHS E-STaR Centers.
Funding Opportunity RFA-AI-24-003 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to support radiation research at all stages of development for the identification of biomarkers of injury and the development of assays or devices for the purpose of triage, including assessing absorbed dose or predicting health outcomes of acute or delayed injuries resulting from radiation exposure during a public health emergency. This NOFO will support the development of these approaches, with the goal of future regulatory approval.
Funding Opportunity PAR-24-111 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support research that improves understanding of basic mechanisms and biomarkers of trained immunity (i.e., innate immune memory), plus the functional implications of trained immunity, related to 1) immune system development and function, 2) immunity to vaccines or natural infections, or 3) allergic diseases, autoimmunity, or rejection of organ/tissue/cell transplantation.
Notice NOT-DK-24-009 from the NIH Guide for Grants and Contracts
Notice NOT-EB-24-004 from the NIH Guide for Grants and Contracts
Notice NOT-AT-24-029 from the NIH Guide for Grants and Contracts