NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity RFA-RM-22-012 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to establish the Tissue Procurement Center for the Somatic Mosaicism across Human Tissues (SMaHT) Network.?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The goal of the Tissue Procurement Center is to collect, process, store, and rapidly distribute to the Network at least 15 high quality, well characterized, human tissues recovered from a minimum of 150 individuals recruited from a diverse pool of donors.
Funding Opportunity RFA-RM-22-011 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites new applications for development of tools and technologies to enhance understanding of somatic variants as part of the Somatic Mosaicism across Human Tissues (SMaHT) Network.?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. Technology and Tools Development Projects will develop the next generation of technologies that will enhance our ability to detect and characterize somatic variants in diverse human types of tissues.
Funding Opportunity RFA-RM-22-010 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to establish the Data Analysis Center (DAC) for the Somatic Mosaicism across Human Tissues (SMaHT) Network. ?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The Data Analysis Center will be responsible for the following areas: 1. Managing all data on behalf of the Network, including ingestion, uniform processing, and standardized annotation, and archiving of data; 2. Developing new computational methods and bioinformatics tools and deploying them as part of an accessible data workbench; 3. Building a data portal for the Network, including the SMaHT Variant Catalog and variant browser, and 4. Harmonizing SMaHT resources with related programs.
Funding Opportunity RFA-RM-22-009 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to establish the Organizational Center for the Somatic Mosaicism across Human Tissues (SMaHT) Network.?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The Organizational Center will coordinate meetings, communication, outreach, and other organizational activities within the Network and be the main conduit for collaboration with related programs and the wider research community.
Notice NOT-AI-22-023 from the NIH Guide for Grants and Contracts
Notice NOT-CA-22-054 from the NIH Guide for Grants and Contracts
Notice NOT-AG-22-014 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-NS-22-049 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse. Projects validating approaches using other species are also permitted if well justified. Applications may address any aspects of the data collection, analysis, and dissemination pipelines, to enable faster and more cost-effective generation and interpretation of brain-wide wiring diagrams. Projects will offer distinct capabilities and competencies aimed at developing and optimizing current technologies or entirely new and potentially risky approaches. They will be integrated into the BRAIN CONNECTS Network, consisting of other Specialized Projects from this FOA, and Comprehensive Centers from its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.
Funding Opportunity RFA-NS-22-047 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of human and non-human primate circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping region-to-region connectivity with a minimum resolution of individual cells and/or axon fibers. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.
Funding Opportunity RFA-NS-22-048 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) supports Comprehensive Centers to develop and test technologies that can be scaled to brain-wide atlases of mouse circuit connectivity. Centers will establish data collection, analysis, and dissemination pipelines to demonstrate the feasibility of mapping cell-to-cell connectivity with a minimum resolution of synaptic connections. They will demonstrate the significance of the approach within the context of a chosen CNS sub-volume, by testing specific hypotheses relating circuit structure to function. They will also incorporate toolsets and infrastructure for integrating separately collected data from smaller volumes, as well as from other data collection modalities, and for enabling the neuroscience community to interact with and mine the data for new research questions. Centers will be integrated into the BRAIN CONNECTS Network, consisting of projects from this FOA and its companion announcements, as a coordinated effort aimed at developing wiring diagrams that can span entire brains across multiple scales.
Funding Opportunity RFA-AG-23-014 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications for projects designed to understand molecular and cellular mechanisms underlying cerebral blood flow reduction in Alzheimers disease (AD) and Alzheimers disease-related dementias (ADRD).
Notice NOT-DE-22-006 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-22-000 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The over-arching goal of this NIBIB R25 program is to support educational activities thatcomplement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development.This FOA seeks to support programs that include innovative approaches to enhance biomedical engineering design education to ensure a future workforce that can meet the nations needs in biomedical research and healthcare technologies. Applications are encouraged from institutions that propose to establish new or to enhance existing team-based design courses or programs in undergraduate biomedical engineering departments or other degree-granting programs with biomedical engineering tracks/minors. This FOA targets the education of undergraduate biomedical engineering/bioengineering students in a team-based environment. While current best practices such as multidisciplinary/interdisciplinary education, introduction to the regulatory pathway and other issues related to the commercialization of medical devices, and clinical immersion remain encouraged components of a strong BME program, this FOA also challenges institutions to propose other novel, innovative and/or ground-breaking activities that can form the basis of the next generation of biomedical engineering design education.
Funding Opportunity RFA-RM-22-001 from the NIH Guide for Grants and Contracts. The Transformative Research to Address Health Disparities and Advance Health Equity at Minority Serving Institutions initiative is soliciting applications to support collaborative investigative teams or individual scientists who propose unusually innovative research projects, which, if successful, would have a major impact in developing, implementing, or disseminating innovative and effective interventions to prevent, reduce, or eliminate health disparities and advance health equity. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in addressing health disparities and advancing health equity.
Notice NOT-DA-22-003 from the NIH Guide for Grants and Contracts
Notice NOT-DA-22-056 from the NIH Guide for Grants and Contracts
Notice NOT-OD-22-078 from the NIH Guide for Grants and Contracts
Notice NOT-DC-22-007 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-22-086 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits grant applications proposing to utilize bacteria, archaebacteria, bacteriophages, or other non-oncolytic viruses and their natural products to study the underlying mechanisms of the complex interactions between microorganisms, tumors, and the immune system, and to explore their clinical potential for cancer imaging, therapeutics or diagnostics. Projects can focus on using microorganisms as anti-tumor agents, as activators of anti-tumor immunity, or as delivery vehicles for treatment, diagnosis, or imaging, complementing or synergizing with existing tools and approaches. This FOA will support basic mechanistic and preclinical studies in cell culture and animal models. Applicants are encouraged to address both the microbial and tumor aspects of microbial tumor interactions relevant to microbial-based cancer therapy (including therapies for oral cancer), tumor imaging, tumor detection, or diagnosis. The R21 FOA is intended to encourage exploratory projects that are at an early conceptual stage feasibility study (inception through preliminary development) to demonstrate the core functional capabilities of the proposed approach. The proposed projects may involve considerable risk and should be aimed at producing breakthroughs in microbial-based cancer therapy, imaging, or diagnosis. This funding opportunity is part of broader NCI-sponsored research on microbial-based cancer therapy.
Funding Opportunity PAR-22-085 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits grant applications proposing to utilize bacteria, archaebacteria, bacteriophages, or other non-oncolytic viruses and their natural products to study the underlying mechanisms of the complex interactions between microorganisms, tumors, and the immune system, and to explore their clinical potential for cancer imaging, therapeutics or diagnostics. Projects can focus on using microorganisms as anti-tumor agents, as activators of anti-tumor immunity, or as delivery vehicles for treatment, diagnosis, or imaging, complementing or synergizing with existing tools and approaches. This FOA will support basic mechanistic and preclinical studies in cell culture and animal models. Applicants are encouraged to address both the microbial and tumor aspects of microbial tumor interactions relevant to microbial-based cancer therapy (including therapies for oral cancer), tumor imaging, tumor detection, or diagnosis. This funding opportunity is part of broader NCI-sponsored research on microbial-based cancer therapy. (link to OCCAM)