NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity RFA-AG-23-010 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to stimulate research in noncoding ribonucleic acids (ncRNAs) to investigate the causality, directionality, mechanisms, and therapeutic potential of ncRNAs in Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). This FOA will support applications seeking to discover novel mechanisms mediated by ncRNAs, elucidate molecular, and cellular functions involved in the pathogenesis and progression of AD/ADRD.
Notice NOT-TR-22-017 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DA-23-006 from the NIH Guide for Grants and Contracts. There has been a substantial increase in the number of syringe service programs (SSPs) in the US and the range of these settings has become broader, with many now located in health department or FQHCs, in addition to the more traditional CBO and AIDS Service Organization settings. There is a need to provide models for bringing sustainable integrated HIV prevention and care into SSP settings. Newer SSPs often are in settings that have limited expertise for other substance use services and may be limited in terms of HIV care. More established SSPs may provide HIV testing, but often do not directly provide other HIV prevention and care services and rely on referrals with limited follow-up. SSPs provide opportunities for regular contact with PWID and their network members (including non-injectors) which may enable greater engagement and re-engagement across the HIV continua of prevention and treatment. Newer SSPs often are in rural areas with limited capacity to provide a range of HIV services and the COVID pandemic has required restructuring of services and has led to some closures. CDC is developing infrastructure to better monitor SSP programs, survey clients, and develop technical assistance models for SSPs. A program of implementation-focused research to improve HIV prevention and care would complement this effort, as well as SAMHSAs support of these settings.
Funding Opportunity RFA-DA-23-007 from the NIH Guide for Grants and Contracts. There has been a substantial increase in the number of syringe service programs (SSPs) in the US and the range of these settings has become broader, with many now located in health department or FQHCs, in addition to the more traditional CBO and AIDS Service Organization settings. There is a need to provide models for bringing sustainable integrated HIV prevention and care into SSP settings. Newer SSPs often are in settings that have limited expertise for other substance use services and may be limited in terms of HIV care. More established SSPs may provide HIV testing, but often do not directly provide other HIV prevention and care services and rely on referrals with limited follow-up. SSPs provide opportunities for regular contact with PWID and their network members (including non-injectors) which may enable greater engagement and re-engagement across the HIV continua of prevention and treatment. Newer SSPs often are in rural areas with limited capacity to provide a range of HIV services and the COVID pandemic has required restructuring of services and has led to some closures. CDC is developing infrastructure to better monitor SSP programs, survey clients, and develop technical assistance models for SSPs. A program of implementation-focused research to improve HIV prevention and care would complement this effort, as well as SAMHSAs support of these settings.
Notice NOT-TR-22-022 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AG-23-015 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications on novel studies of the cytosolic DNA sensing mechanisms in the interactions of the aging hallmarks. The goal of this FOA is to support applications that will lead to an in-depth understanding of the molecular mechanisms that determine the effects of cytosolic DNAs on aging hallmarks in the context of aging and longevity. Research supported by this FOA should lead to new insights to address some critical mechanistic questions relevant to the role of aging hallmarks in aging and aging-related diseases. This FOA encourages innovative, mechanistic approaches to identify and characterize interactions of aging hallmarks mediated by cytosolic DNAs that ultimately modulate the regulation of healthspan and/or longevity.
Funding Opportunity RFA-AG-23-013 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits research projects with the goal of increasing our understanding of the interactions among hallmarks of aging and their regulation. Research supported by this FOA should explore the timing and possible priorities (hierarchy) among the hallmarks in various cells/tissues across the normal lifespan, and whether the interactions between the hallmarks are an adaptive response to maintain health at different stages of life. This is one of three inter-connected FOAs with an overarching focus on the interactions of aging hallmarks as a framework for innovative research in aging biology.
Funding Opportunity RFA-AG-23-012 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages innovative, mechanistic approaches to identify and characterize interactions of aging hallmarks shaped by inter-organelle communication.
Funding Opportunity PAR-22-114 from the NIH Guide for Grants and Contracts. The purpose of this trans-NCI Funding Opportunity Announcement (FOA) is to promote new cancer disparities research among investigators who do not normally conduct it and to encourage the partnership of experienced cancer research investigators with cancer disparities-focused researchers. This FOA is intended to accelerate and strengthen multi-disciplinary cancer disparities research in wide ranging areas. Cancer disparities research includes, but is not limited to basic, translational, behavioral, observational, interventional, environmental and population research studies that address the adverse differences in cancer incidence, prevalence, mortality, survivorship, burden and/or response to treatment in racial/ethnic minorities and/or underserved population groups. Proposed collaborations should focus on achieving research objectives that by necessity rely on diverse and complementary expertise, technical capabilities, and resource sets. Importantly, the supplemental request is required to be within the scope of the parent award and should expand the original aims to include a cancer disparity component and possible inclusion of international comparator cohorts. A trans NCI effort, the concept reissuance of the Collaborative Program is supported by NCIs Division of Cancer Biology (DCB), Division of Cancer Treatment and Diagnosis (DCTD), Division of Cancer Prevention (DCP), Division of Cancer Control and Population Sciences (DCCPS), Center to Reduce Cancer Health Disparities (CRCHD) and now, also included Center for Global Health.
Notice NOT-AI-22-029 from the NIH Guide for Grants and Contracts
Notice NOT-AT-22-010 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AI-22-012 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to participate in the Immune Drivers of Autoimmune Disease (IDAD) cooperative research program, which will focus on defining the immunologic states and dynamics that drive autoimmune disease. The main objective of this program is to enhance our understanding of the immunologic processes, events, and changes that underlie the clinical manifestations of autoimmune diseases, including disease flare, remission, and progression of established disease, as well as the progression from a state of elevated risk to clinical diagnosis of autoimmune disease.
Notice NOT-AI-22-032 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AI-22-010 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit research applications for projects focused on development and/or production of medical diagnostics that permit rapid differential species identification, and corresponding phenotypic antibacterial susceptibility profiles for bacteremia or hospital acquired pneumonia. The primary goal of such diagnostics is to facilitate antibacterial stewardship, thereby reducing selective pressure and improving patient outcomes.
Notice NOT-NS-22-083 from the NIH Guide for Grants and Contracts
Notice NOT-DA-22-004 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-HL-23-018 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) will support meritorious exploratory research relevant to the NHLBI mission (http://www.nhlbi.nih.gov/about/org/mission) using the existing biospecimen collections that are stored in the NHLBI Biologic Specimen Repository (Biorepository), thereby maximizing the scientific value of the stored collections and providing researchers with an opportunity to generate preliminary data for subsequent research proposals.
Funding Opportunity PAR-22-089 from the NIH Guide for Grants and Contracts. The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and/or early evaluation of strong candidate biomarkers and biomarker signatures that can be used as tools to facilitate the clinical development of neurotherapeutics and their use in clinical practice. Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical evaluation of biomarkers and biomarker signatures for neurological and neuromuscular disorders. Although research supported by this FOA can include animal studies, it must also include preliminary human evaluation using carefully standardized human samples or datasets. The goal of this initiative is to deliver candidate biomarkers or biomarker signatures that are ready for definitive analytical and clinical validation studies.
Funding Opportunity RFA-AG-23-007 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites research to develop, validate, and disseminate measurement tools that could be used to screen for deficits related to decision-making, planning, and other important higher order functional outcomes in older adults. In particular, we are interested in instruments that can track changes in decision-making capacity that could be useful in the context of future screening for cognitive impairment and the development of interventions targeting functional outcomes in persons living with cognitive impairment and/or quality of life outcomes in their care partners/caregivers. The goal of the FOA is to support a research network whose goals would be to review and assess the dimensions of higher cognitive abilities and functional capacities already believed to support higher order planning and decision-making, to develop valid and reliable measures of those abilities, and to provide support for pilot efforts during the instrument development and validation in a racially, ethnically, geographically, and diagnostically diverse set of participants as well as a set of enduring resources including the measurement instruments, documentation, and normative data that will enable other, future projects to incorporate the new measurements into studies.
Funding Opportunity RFA-RM-22-013 from the NIH Guide for Grants and Contracts. This funding opportunity announcement invites applications to establish the Genome Characterization Centers (GCCs) for the Somatic Mosaicism across Human Tissues (SMaHT) Network. ?The purpose of the SMaHT Network is to enable discovery of new biology and disease mechanisms mediated by genomic variation in somatic tissues. The GCCs will be responsible for generating state of the art, high throughput genomic data characterizing somatic variants in a set of 10-15 human tissues from 150+ donors. The GCCs will work closely with the SMaHT Data Analysis Center to build the framework for a comprehensive catalog of variants.