NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-MH-22-280 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-HD-23-013 from the NIH Guide for Grants and Contracts. This FOA invites applications to participate in a research program cooperative agreement to support the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN). The Network will expand successes achieved by PATC3H to new geographic settings with limited implementation science (IS) research capacity and/or risk populations who are poorly represented in international adolescent HIV research (e.g. sexual and gender minorities; commercial sex workers; drug users) and stimulate much needed IS research in a neglected area of public health significance: prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). These settings must have an HIV epidemic density defined by UNAIDS estimates as either a country 1) in which at least 200,000 people are living with HIV and the number has not decreased by more than 5% over the last 2 consecutive years of available data or 2) has an HIV incidence among youth ages 10 to 24 years of 0.01% or more.
Funding Opportunity RFA-HD-23-014 from the NIH Guide for Grants and Contracts. This FOA invites applications to participate in a research program cooperative agreement to support the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings Implementation Science Network (PATC3H-IN). The Network will expand successes achieved by PATC3H to new geographic settings with limited implementation science (IS) research capacity and/or risk populations who are poorly represented in international adolescent HIV research (e.g. sexual and gender minorities; commercial sex workers; drug users) and stimulate much needed IS research in a neglected area of public health significance: prevention of new HIV infections among adolescents at risk and the identification of, and linkage and retention to care of and long-term viral suppression among youth living with HIV in low-to-middle income countries (LMICs). These settings must have an HIV epidemic density defined by UNAIDS estimates as either a country 1) in which at least 200,000 people are living with HIV and the number has not decreased by more than 5% over the last 2 consecutive years of available data or 2) has an HIV incidence among youth ages 10 to 24 years of 0.01% or more.
Funding Opportunity RFA-MH-22-240 from the NIH Guide for Grants and Contracts. The goal of this effort is to support the development and validation of next generation platforms and analytic approaches to precisely quantify behaviors in humans and link them with simultaneously recorded brain activity. Tools used for analyzing behavior should be multi-modal and should be able to be linked to brain activity and thus have the accuracy, specificity, temporal resolution, and flexibility commensurate with tools used to measure and modulate the brain circuits that give rise to those behaviors. This phased award will support novel tool development (i.e., hardware/software) in the R61 phase and synchronization of novel tools for measuring behavior and human brain activity in the R33 phase.
Funding Opportunity RFA-NS-23-004 from the NIH Guide for Grants and Contracts. The purpose of this Limited Competition Funding Opportunity Announcement is to allow Undiagnosed Diseases Network (UDN) Clinical Sites that received an NIH award under RFA-RM-17-019 an opportunity to compete for one additional year of NIH funding to: continue their participation in the UDN; establish collaborations and efficient processes with the next phase Data Management and Coordinating Center (DMCC; see: RFA-NS-22-051); enroll and evaluate new participants; and further develop their sustainability plans.
Notice NOT-HL-22-041 from the NIH Guide for Grants and Contracts
Notice NOT-OD-22-186 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DK-22-019 from the NIH Guide for Grants and Contracts. This U2C funding opportunity announcement (FOA) is a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) initiative to establish a novel national Stakeholder Engagement Innovation Center for advancing equity in type 1 diabetes research (SEIC-T1D). A primary goal of the SEIC-T1D is to accelerate equitable engagement of diverse stakeholders in T1D research, particularly those from diverse communities that experience diabetes-related health disparities, as well as the healthcare and social systems that impact community members and patients health. The SEIC-T1D will provide highly specialized research resources to support investigators by fully embedding communities, people living with T1D, and other stakeholders into the full spectrum of research activities through expert consultations and education in principles and methods of community-engaged research. The SEIC-T1D will also establish a network consisting of diverse, multidisciplinary research investigators with expertise in T1D and community-engaged methods, community experts with lived experiences, and representatives of various health and other organizations deemed essential for addressing disparities and advancing health equity in T1D early detection and treatment.
Notice NOT-CA-22-108 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DK-22-503 from the NIH Guide for Grants and Contracts. The purpose of this Limited Competition is to extend the Chronic Renal Insufficiency Cohort (CRIC) Study by continuing to support the Scientific and Data Coordinating Center (SDCC). The CRIC Study is a multi-center, prospective, observational cohort study of men and women with chronic kidney disease (CKD). The CRIC Clinical Centers will complete follow-up previously enrolled participants under a separate FOA with a focus on completing enrollment into ongoing sub-studies that utilize at-home assessments of kidney and cardiovascular function. The primary objective of this FOA is to support the SDCC to lead the study group to achieve the scientific goals of the next project period and develop a sustainable strategy to disseminate the CRIC data and samples to the larger research community, as well as ensure that all study samples and data are archived into the NIDDK Central Repository.
Funding Opportunity RFA-NS-22-055 from the NIH Guide for Grants and Contracts. This FOA invites applications that propose the comprehensive functional validation of newly identified therapeutic target candidates for Alzheimer's Disease-Related Dementias (ADRDs). This FOA seeks to promote critical target validation approaches to help de-risk subsequent translational research and accelerate the advancement of novel therapies for ADRD. Target(s) or molecular pathway(s) to be considered for validation must have been already identified using tissue expression or genetic data generated in human samples. In its initial phase, this FOA provided support for up to two years (R61 stage) for the development of customized technologies, models, and protocols to modulate the expression or activity of target candidate(s) in cells or tissues and monitor their functional biological consequences in in vitro or in vivo disease models. Upon demonstration of technical feasibilities, a second phase (R33 stage) will carefully and reproducibly measure and cross-validate the impact of the target modulation in different modalities across collaborating laboratories using the NIH rigor and reproducibility guidelines. Applicants responding to this FOA must address objectives for both the UG3 and UH3 phases and are expected to have a substantial collaborative effort between independents laboratories. This FOA is not specific for any one or group within the ADRD spectrum of disorders. Disorders covered in these applications are frontotemporal degeneration (FTD), Lewy body dementias (LBD) (including dementia with Lewy bodies (DLB)), Parkinson disease dementia (PDD), vascular contributions to cognitive impairment and dementia (VCID), mixed dementias including the associated diagnostic challenges of multiples etiology dementias (MED).
Funding Opportunity RFA-NS-22-053 from the NIH Guide for Grants and Contracts. Emergency Award: This Funding Opportunity Announcement (FOA) solicits research applications that propose implementation science methodology to embed existing evidence-based coordinated pain care models into a variety of public and private health care systems (HCS) where this type of care does not exist. Applications that combine comparative effectiveness studies of innovative coordinated care models with strong implementation science methodology to embed effective approaches into HCSs also are encouraged. This FOA requires that the coordinated care model under study be embedded into the health care delivery system of the applicant institutions. Coordinated pain care approaches proposed for study should include interventions from multiple disciplines as described below and should aim to improve pain management based on the biopsychosocial model of pain. Emphasis should be on populations of patients with greatest need. This FOA solicits applications from HCS who have resources and infrastructure to support research and implementation of study approaches in partnership with those HCS who lack research resources or experience and would benefit most from implementation of cost-effective coordinated pain care. HCS partners who serve populations that are under-represented in research are encouraged to apply. Models of coordinated care proposed by the study team should be aligned with health care resources of the participating HCS and should be informed through engagement of stakeholders including patients, providers, healthcare system executives, policy makers, and payors. The study teams must include health care providers from multiple disciplines and implementation scientists.
Funding Opportunity RFA-NS-22-065 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to solicit applications for a Coordinating Center to provide leadership for the HEAL Coordinated Approaches to Pain Care in Health Care Systems Program. The Coordinating Center will 1) work collaboratively with each Project team supported through the Collaboratory program, including their partnering health care system (HCS), to develop, test, and implement the proposed Projects while providing technical, design, and coordination support; 2) provide centralized resources (e.g., electronic health records expertise, study design and statistical expertise for implementation trials, bioethics and regulatory expertise) for coordination and integration of the research effort across all projects; and 3) centralize the engagement of patients, care providers, health care systems, payors, and policy makers to inform the activities of the program of research, with a particular focus on HCS with less historical involvement in research studies. The Coordinating Center also will serve as the central administrative resource for the activities of the Coordinated Approaches to Pain Care Program.
Notice NOT-AI-22-061 from the NIH Guide for Grants and Contracts
Notice NOT-AI-22-062 from the NIH Guide for Grants and Contracts
Notice NOT-AI-22-063 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-MH-22-190 from the NIH Guide for Grants and Contracts. This NIMH funding opportunity announcement (FOA) seeks to strengthen the evidence for effective interventions and implementation strategies that address SDoH for HIV, and ultimately improve HIV outcomes and reduce health inequities. The FOA will solicit and fund a set of implementation research projects that aim to reduce HIV inequities, with the goal to support high-impact implementation research in HIV health inequity reduction and develop a generalizable knowledge base to guide implementation of innovative strategies, inform policy, shape guidelines, and provide a model for other jurisdictions. Research projects or collaboratives will employ efficient hybrid implementation-effectiveness research designs to simultaneously advance the evidence base for effective SSDoH-encompassing interventions and test implementation strategies to accompany these interventions.
Funding Opportunity RFA-MH-22-191 from the NIH Guide for Grants and Contracts. This NIMH funding opportunity announcement (FOA) seeks to strengthen the evidence for effective interventions and implementation strategies that address SDoH for HIV, and ultimately improve HIV outcomes and reduce health inequities. The FOA will solicit and fund a set of implementation research projects that aim to reduce HIV inequities, with the goal to support high-impact implementation research in HIV health inequity reduction and develop a generalizable knowledge base to guide implementation of innovative strategies, inform policy, shape guidelines, and provide a model for other jurisdictions. Research projects or collaboratives will employ efficient hybrid implementation-effectiveness research designs to simultaneously advance the evidence base for effective SSDoH-encompassing interventions and test implementation strategies to accompany these interventions.
Notice NOT-TR-22-033 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AI-22-046 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support research on the underlying cause(s) of signs and symptoms that may persist following a Lyme disease diagnosis and antibiotic treatment.