NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-NS-24-103 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-MH-25-160 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support formative research and pilot testing of culturally sensitive, innovative interventions to identify and mitigate the risk of suicidal ideation and behavior (SIB), and/or non-suicidal self-injury (NSSI) in Low- and Middle-Income Countries (LMICs). The proposed research initiatives must incorporate a plan to strengthen research capacity within the LMIC community where the study will be conducted.
Notice NOT-CA-24-056 from the NIH Guide for Grants and Contracts
Notice NOT-EY-24-007 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-NS-25-011 from the NIH Guide for Grants and Contracts. This NOFO invites applications that propose the comprehensive functional validation of newly identified therapeutic target candidates for Alzheimer's Disease-Related Dementias (ADRDs). This NOFO seeks to promote critical target validation approaches to help de-risk subsequent translational research and accelerate the advancement of novel therapies for ADRD. Target(s) or molecular pathway(s) to be considered for validation must have been already identified using tissue expression or genetic data generated in human samples. In its initial phase, this FOA provided support for up to two years (R61 stage) for the development of customized technologies, models, and protocols to modulate the expression or activity of target candidate(s) in cells or tissues and monitor their functional biological consequences in in vitro or in vivo disease models. Upon demonstration of technical feasibilities, a second phase (R33 stage) will carefully and reproducibly measure and cross-validate the impact of the target modulation in different modalities across collaborating laboratories using the NIH rigor and reproducibility guidelines. Applicants responding to this NOFO must address objectives for both the R61 and R33 phases and are expected to have a substantial collaborative effort between independents laboratories. This NOFO is not specific for any one or group within the ADRD spectrum of disorders. Disorders covered in these applications are frontotemporal degeneration (FTD), Lewy body dementias (LBD) (including dementia with Lewy bodies (DLB)), Parkinson disease dementia (PDD), vascular contributions to cognitive impairment and dementia (VCID), mixed dementias including the associated diagnostic challenges of multiples etiology dementias (MED).
Notice NOT-DE-24-019 from the NIH Guide for Grants and Contracts
Notice NOT-OD-24-129 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DA-25-056 from the NIH Guide for Grants and Contracts. There is a lack of early translational funding and technical support for new product developers to move beyond the idea stage and into the product development space. Establishing a technical development center (or centers) will assist researchers developing new digital therapeutics for SUD. These centers will provide idea developers with technical development support to prepare the PI for future funding applications (e.g. Phase I SBIR, other NIH research grants, Blueprint Neurotherapeutics or Blueprint MedTech, etc.). The technical development assistance will include support from experts in the idea to product translation activities including the following: target product profile development clinical need assessment project plan development with timeline and milestones prototype development proof-of-concept study design preliminary safety assessments assistance in understanding current and future regulatory requirements
Funding Opportunity RFA-DC-24-008 from the NIH Guide for Grants and Contracts. NIDCD invites applications for formative dissemination and implementation (D and I) research projects in NIDCD mission areas of hearing, balance, taste, smell, voice, speech, and language.
Notice NOT-NS-24-077 from the NIH Guide for Grants and Contracts
Notice of Participation of the National Institute on Aging in PAR-23-285, PAR-23-298, and PAR-23-299
Notice NOT-AG-24-018 from the NIH Guide for Grants and Contracts
Notice NOT-AG-24-012 from the NIH Guide for Grants and Contracts
Notice NOT-DA-24-032 from the NIH Guide for Grants and Contracts
Notice NOT-MD-24-018 from the NIH Guide for Grants and Contracts
Notice NOT-CA-24-050 from the NIH Guide for Grants and Contracts
Notice NOT-DA-24-029 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DA-24-041 from the NIH Guide for Grants and Contracts. This Brain-Behavior Quantification and Synchronization notice of funding opportunity (NOFO) seeks applications proposing research aiming to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the organismal level, with synchronous capture of changes in the organisms social or physical environment; and 2) develop computational methods that allow for integration of multidimensional behavioral and environmental data representing multiple timescales into a conceptual and/or computational model of behavior as a complex dynamic system. Proposed projects are also expected to be designed with the capacity to integrate synchronously recorded neural data and/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative. Research that falls under the definition of an NIH Clinical Trial is not allowed under this NOFO. Applicants interested in proposing mechanistic research in humans relevant to the above purpose should submit under the companion U01 NOFO, RFA-DA-24-040. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete and will be withdrawn. Applicants are strongly encouraged to read the NOFO instructions carefully and view the available PEDP guidance material.
Funding Opportunity RFA-DA-24-040 from the NIH Guide for Grants and Contracts. This Brain-Behavior Quantification and Synchronization notice of funding opportunity (NOFO) seeks applications that bring together transdisciplinary teams and aim to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution objective measurement of behavior at the organismal level, with synchronous capture of dynamic environmental data; 2) develop advanced analytic approaches to integrate multidimensional behavioral, neural and environmental data; and 3) develop and test new theoretical and computational models aiming to advance understanding of behavior as a complex dynamic system. Proposed projects are expected to be designed with the capacity to integrate synchronously recorded neural data and/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative. This BRAIN Initiative NOFO is specifically soliciting applications proposing basic research involving human subjects aiming to reveal and understand fundamental principles underlying behavioral function, including research limited to observational studies or analysis of human data. Applications proposing research using exclusively non-human animal models should apply under the companion NOFO, RFA-DA-24-041. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP).
Notice NOT-MH-24-335 from the NIH Guide for Grants and Contracts
Notice NOT-MH-24-321 from the NIH Guide for Grants and Contracts