NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-DA-19-055 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-19-299 from the NIH Guide for Grants and Contracts. The goal of the Bridges to the Baccalaureate Research Training Program is to provide structured activities to prepare community college students to transfer to and complete a bachelor's degree in biomedical research fields. This funding opportunity announcement (FOA) provides support to eligible, domestic institutions to develop and implement effective, evidence-based approaches to biomedical training and mentoring that will keep pace with the rapid evolution of the research enterprise. NIGMS expects that the proposed research training programs will incorporate didactic, research, mentoring, and career development elements to prepare trainees to bridge from the community college and complete the bachelor's degree in biomedical fields. This program requires partnerships between two-year post-secondary educational institutions granting the associate degree with four-year colleges or universities that offer the baccalaureate degree. This FOA does not allow appointed trainees to lead an independent clinical trial but does allow them to obtain research experience in a clinical trial led by a mentor or co-mentor.
Notice NOT-MH-19-034 from the NIH Guide for Grants and Contracts
Notice NOT-MH-19-033 from the NIH Guide for Grants and Contracts
Notice NOT-DA-19-056 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-19-298 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to encourage applications for studies using non-invasive neurostimulation/neuromodulation in the treatment of Alzheimer's Disease (AD) or Alzheimer's disease-related dementias (ADRD). The goal of this FOA is to establish initial efficacy of neurostimulation/neuromodulation in the treatment of AD/ADRD or to refine these interventions for AD/ADRD patients. Multimodal or combination interventions are allowed, provided the focus and innovative component is neurostimulation.
Funding Opportunity RFA-NS-19-039 from the NIH Guide for Grants and Contracts. (Reissue of RFA-NS-16-021, PAR-18-413) Diffuse brain white matter disease is highly prevalent in the elderly, and has been clinically associated with vascular contributions to cognitive impairment and dementia (VCID) in both men and women. Diffuse white matter disease is thought to include a variety of pathologies including demyelination and/or fiber loss due to multifocal infarction and local ischemia. It is often accompanied by arteriosclerosis in deep penetrating arteries, multiple infarcts in the basal ganglia, brainstem or cerebellum. Though most commonly extending out from the periventricular surfaces, it may also occur in subcortical white matter. Diffuse white matter disease is typically detected in clinical settings as hyperintensity on magnetic resonance imaging (MRI) or signal loss on computed tomography x-ray (CT) scan; diffuse white matter disease can be detected histologically as well, for example in human pathology and in studies using animal models. Despite the prevalence and potential significance of white matter disease for cerebrovascular disease etiology and cognitive outcomes, much remains to be learned about the cellular and molecular causes, regional vulnerability, and progression over time. The physiological consequences of diffuse white matter disease on local axon and neural circuit function are almost completely unknown. The purpose of this FOA is to address some of the many gaps in knowledge of the biologic mechanisms of the commonly occurring, cerebrovascular disease and age-related diffuse white matter disease at the molecular, cellular, tissue and brain circuit level. The ultimate goal of this fundamental research is to inform future efforts to reduce the burden of illness due to age-related vascular contributions to cognitive impairment and dementia.
Notice NOT-OD-19-107 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-ES-19-010 from the NIH Guide for Grants and Contracts. The goal of this NIEHS undergraduate research education R25 program is to support educational activities that enhance the diversity of the biomedical, behavioral and clinical research workforce in the environmental health sciences. To this end, this funding opportunity announcement (FOA) encourages the development of creative educational activities with a primary focus on research experiences for undergraduates at the junior and senior level.
Funding Opportunity RFA-AG-20-007 from the NIH Guide for Grants and Contracts. The primary aim of this Funding Opportunity Announcement (FOA) is to facilitate the characterization of the marmoset as a laboratory animal for research on aging and age-related diseases.
Funding Opportunity RFA-TR-19-014 from the NIH Guide for Grants and Contracts. This FOA invites applications for projects designed to test the effectiveness of microphysiological systems (MPS), also called tissue chip, technology, for clinical trial frameworks by demonstrating their applied use in clinical trial planning and execution, addressing both safety and efficacy in late-stage preclinical studies. This approach is to provide evidence of the utility of tissue chip technology for precision medicine in informing trial design, establishing recruitment criteria and stratification of patient populations in identifying the best responders to candidate therapeutics.
Notice NOT-MH-20-022 from the NIH Guide for Grants and Contracts
Notice NOT-NS-19-058 from the NIH Guide for Grants and Contracts
Notice NOT-NS-19-068 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-MH-20-215 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Institute of Mental Health (NIMH) seeks applications to develop, sustain, enhance, and enrich a centralized national biorepository for genetic studies of psychiatric disorders for facilitation and acceleration of the scientific understanding of the genetic risk architecture underlying mental disorders. This effort is expected to involve a functionally integrated, multi-disciplinary team that will provide for open sharing of biosamples and data resources through a single, centralized, national resource to advance basic and translational research in the genetics of mental disorders.
Funding Opportunity RFA-AG-20-022 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications to conduct new research on automobile technology for signaling early signs of cognitive impairment in older drivers.
Notice NOT-MH-19-030 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-19-297 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks to support collaborative clinical studies, not involving treatment development, efficacy, or effectiveness trials. Primary areas of focus include mental health genetics, biomarker studies, and studies of mental illnesses (e.g., psychopathology, neurodevelopmental trajectories of psychopathology) also when associated with HIV/AIDS. Applicants should apply to this FOA when two or more sites are needed to complete the study. Accordingly, the collaborating studies share a specific protocol across the sites and are organized as such in order to increase sample size, accelerate recruitment, or increase sample diversity and representation. In studies with a large number of sites, it is expected that one site will be submitted as a coordinating R01 for data management and/or other centralized administration.
Notice NOT-CA-19-053 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-19-295 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages solicits applications that propose research designed to test training, mentoring, and networking interventions intended to enhance research-oriented individuals' interest, motivation, persistence and preparedness for careers in the biomedical research workforce. Funded projects are expected to produce research findings that will guide the design and implementation of potential interventions in a variety of academic settings and career levels to enhance the diversity of the biomedical research workforce.