NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity RFA-TR-21-001 from the NIH Guide for Grants and Contracts. The purpose of the ASPIRE Collaborative Research Program is to facilitate translational and clinical research between NCATS intramural scientists and the extramural community to develop approaches that will enhance the ability to discover and develop new chemistries towards previously undrugged biological targets (i.e., biological targets with no known drugs to modulate their function) across many human diseases and conditions. NCATS intramural scientists have established an integrated NCATS ASPIRE platform consisting of physical and virtual modules for automated synthetic chemistry, artificial intelligence (AI) and machine learning (ML), engineering, informatics, and biological testing. The FOA will support intramural - extramural collaborations to develop additional physical modules that will enhance the platforms capabilities. The anticipated outcome includes identification, design, synthesis, and validation of new chemical entities as starting points for drug development of novel targets, and the expansion of chemical space available for drug screening.
Funding Opportunity RFA-TR-21-002 from the NIH Guide for Grants and Contracts. The purpose of the ASPIRE Collaborative Research Program is to facilitate translational and clinical research between NCATS intramural scientists and the extramural community to develop approaches that will enhance our ability to discover and develop new chemistries designed towards previously undrugged biological targets (i.e., biological targets with no known drugs to modulate their function) across many human diseases and conditions. NCATS intramural scientists have established an integrated platform consisting of physical and virtual modules for automated synthetic chemistry, artificial intelligence (AI) and machine learning (ML), engineering, informatics, and biological testing. This FOA will support intramural - extramural collaborations to develop virtual modules that will enhance the platforms capabilities (see companion RFA-TR-21-001 for physical modules). The anticipated outcome includes identification, design, synthesis, and validation of new chemical entities as starting points for drug development of novel targets, and the expansion of chemical space available for drug screening.
Funding Opportunity RFA-AG-22-002 from the NIH Guide for Grants and Contracts. This FOA seeks to support studies on normal and pathobiological changes in aging bone marrow that impact, or are impacted by, changes in immune function with age. Studies to be supported are in the field of osteoimmunology, which concerns the bidirectional interactions between bone and the immune system. The importance of osteoimmunology and its potential for improving the understanding of bone homeostasis is now recognized. However, most research has been conducted in young mice (3-4 months) that have not completed growth and development. Young animals cannot exhibit the relevant age-associated changes in immune function in the marrow niche that can best be revealed by comparison of older mice (at or older than 18 months) to young adult mice (at least 4 months of age). While important insights have been gained about osteoimmunological signaling pathways in the bone marrow niche of young adults, this approach has not addressed important questions more directly focused on age-related bone loss and the myriad of complex tissue interactions one expects, since bone is an endocrine organ. Pathobiological changes that occur in the aging marrow niche, such as myeloid skewing and declining immune function, are well-documented in the field of immunology. In addition, the role of T cells in osteoclast differentiation, bone resorption, and bone turnover have been demonstrated. However, many questions remain regarding how and why these changes occur over time in both healthy adults and older adults where bone loss is more commonly a major concern. The effect of age on healthy (adaptive) and pathobiological (maladaptive) changes that occur in the aging marrow niche and how these changes affect health trajectories in age-appropriate laboratory animals are the focus of this FOA.
Notice NOT-DK-21-008 from the NIH Guide for Grants and Contracts
Notice NOT-DK-21-010 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-MH-21-117 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support studies to better understand the underlying mechanisms and interplay of biological, psychosocial and structural factors contributing to mood disorders in people living with HIV. Exploratory and high-risk research projects are appro?priate for this funding opportunity announcement. Applications testing a fully conceptualized and hypothesis-based solid premise founded with adequate preliminary data should consider applying to the companion R01 announcement RFA-MH-21-116. Basic and preclinical research in domestic and international settings are of interest. Multidisciplinary research teams and collaborative alliances are encouraged but not required.
Funding Opportunity RFA-MH-21-116 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support studies to better understand the underlying mechanisms and interplay of biological, psychosocial and structural factors contributing to mood disorders in people living with HIV. Applications testing a fully conceptualized and hypothesis-based solid premise founded with adequate preliminary data are appropriate for this funding opportunity announcement. Exploratory and high-risk research projects should c?onsider applying to the companion R21 announcement RFA-MH-21-117. Basic and preclinical research in domestic and international settings are of interest. Multidisciplinary research teams and collaborative alliances are encouraged but not required.
Funding Opportunity RFA-CA-21-002 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for Cellular Cancer Biology Imaging Research (CCBIR) Centers. The Centers will develop and test enabling imaging technologies at the cellular and organ scales driven by specific fundamental questions in cancer biology. The overall purpose of the CCBIR initiative is to facilitate innovation in advanced imaging technologies that could be applied to fundamental basic and pre-clinical research problems in cancer biology. CCBIR Centers are structured to operate collaboratively between technology developers and cancer biologists at the forefront of their respective fields. CCBIR Centers will increase in experimental sophistication over time to ultimately produce an interoperable suite of state-of-the-art imaging technologies with transformative potential to study the cancer biology process(es) that defines the Center. The cadre of CCBIR Centers will form a consortium that will be expected to engage with the broader cancer research community.
Notice NOT-OD-21-037 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-21-074 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NHGRI R25 program is to support educational activities and mentored genomic research experiences for genetic counselors. This program will provide supervised career development experiences to genetic counselors in genomic research through courses, enhance research experiences and mentoring to gain the necessary knowledge and experience to participate and lead future genomic research efforts. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Research Experiences. A secondary focus are mentoring activities and courses for skills development. Applications that demonstrate the potential to recruit genetic counselors from diverse backgrounds to genomics research are particularly encouraged.
Notice NOT-DK-21-009 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-21-075 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this NHGRI R25 program is to support research experiences in genomic data science for masters degree students who are not enrolled in a doctoral program. NHGRI seeks to focus on two objectives (a) encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in genomic data science research; (b) help recruit individuals with specific specialty or disciplinary backgrounds into research careers in genomic data science and foster a better understanding of genomics and its implications. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Research Experiences. Secondary focus is on Courses for Skills Development and Mentoring Activities.
Notice NOT-AA-20-025 from the NIH Guide for Grants and Contracts
Notice NOT-GM-21-010 from the NIH Guide for Grants and Contracts
Notice NOT-GM-21-011 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AR-22-001 from the NIH Guide for Grants and Contracts. NIAMS Centers of Research Translation (CORT) (P50 - Clinical Trial Not Allowed)
Notice NOT-CA-21-021 from the NIH Guide for Grants and Contracts
Notice NOT-EY-21-006 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-RM-20-022 from the NIH Guide for Grants and Contracts. The purpose of the FIRST Cohort is to transform culture at NIH-funded extramural institutions by building a self-reinforcing community of scientists committed to diversity and inclusive excellence (defined below). This community will be built through recruitment of a diverse group of early-career faculty who are competitive for an advertised research tenure-track or equivalent faculty position and who have demonstrated strong commitment to promoting diversity and inclusive excellence.
Funding Opportunity RFA-RM-20-023 from the NIH Guide for Grants and Contracts. The purpose of the NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Coordination and Evaluation Center (CEC), is to coordinate and facilitate the development of strategies with FIRST Cohort awardees to conduct a comprehensive evaluation of the FIRST program.