NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity RFA-DA-21-022 from the NIH Guide for Grants and Contracts. The NIH Helping to End Addiction Long-termSM (HEAL) Initiative and the National Institute on Drug Abuse (NIDA), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Eunice Kennedy Shriver Institute of Child Health and Human Development (NICHD), the Office of Behavioral and Social Sciences Research (OBSSR), the Office of Research on Womens Health (ORWH), the National Institute of Environmental Health Sciences (NIEHS), the National Institute on Minority Health and Health Disparities (NIMHD), and the Environmental influences on Child Health Outcomes (ECHO) Program, intend to jointly fund the HEALthy Brain and Child Development (HBCD) Study using the cooperative agreement award mechanism. This Funding Opportunity Announcement (FOA) solicits applications for the HBCD Consortium Administrative Core. This FOA runs in parallel with companion FOAs that solicit applications for a single Data Coordinating Center (RFA-DA-21-023) and multiple Research Project Sites (RFA-DA-21-020 and RFA-DA-21-021). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.
Funding Opportunity RFA-DA-21-023 from the NIH Guide for Grants and Contracts. The NIH Helping to End Addiction Long-termSM (HEAL) Initiative and the National Institute on Drug Abuse (NIDA), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Eunice Kennedy Shriver Institute of Child Health and Human Development (NICHD), the Office of Behavioral and Social Sciences Research (OBSSR), the Office of Research on Womens Health (ORWH), the National Institute of Environmental Health Sciences (NIEHS), the National Institute on Minority Health and Health Disparities (NIMHD), and the Environmental influences on Child Health Outcomes (ECHO) Program, intend to jointly fund the HEALthy Brain and Child Development (HBCD) Study using the cooperative agreement award mechanism. This Funding Opportunity Announcement (FOA) solicits applications for a Data Coordinating Center. This FOA runs in parallel with companion FOAs that solicit applications for research project sites (RFA-DA-21-020 and RFA-DA-21-021) and a single Consortium Administrative Core (RFA-DA-21-022). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.
Notice NOT-CA-21-029 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DA-21-021 from the NIH Guide for Grants and Contracts. The NIH Helping to End Addiction Long-termSM (HEAL) Initiative and the National Institute on Drug Abuse (NIDA), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Eunice Kennedy Shriver Institute of Child Health and Human Development (NICHD), the Office of Behavioral and Social Sciences Research (OBSSR), the Office of Research on Womens Health (ORWH), the National Institute of Environmental Health Sciences (NIEHS), and the National Institute on Minority Health and Health Disparities (NIMHD), intend to jointly fund the HEALthy Brain and Child Development (HBCD) Study using the cooperative agreement award mechanism. This Funding Opportunity Announcement (FOA) solicits applications for unlinked Research Project Sites. This FOA runs in parallel with companion FOAs that solicit applications for linked Research Project Sites (RFA-DA-21-020), a single Consortium Administrative Core (RFA-DA-21-022) and a single Data Coordinating Center (RFA-DA-21-023). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.
Funding Opportunity RFA-DA-21-020 from the NIH Guide for Grants and Contracts. To address critical questions surrounding the long-term impact of substance exposure on child development, the NIH seeks to create a large, diverse cohort of pregnant women, who along with their offspring, will be followed for 10 years. The cohort will consist of mother and baby dyads recruited beginning in the 2nd trimester of pregnancy and through birth; and will include babies exposed pre- or perinatally to prescription and illicit opioids, marijuana, stimulants, alcohol and nicotine. A deep, nuanced understanding of factors that affect a childs health, brain, and behavioral development is expected to emerge from this study, which is an essential first step toward designing policies and interventions that promote well-being and resiliency in children. Applications are sought from qualified researchers with the capacity and expertise to recruit and retain vulnerable populations for studies that will include neuroimaging, cognitive and behavioral assessments along with collection and analysis of biospecimens from mom and baby.
Funding Opportunity RFA-HD-21-031 from the NIH Guide for Grants and Contracts. This FOA invites applications for Clinical Centers to design and implement a multi-center, comparative effectiveness, randomized controlled trial (RCT) to assess the optimal pharmacological treatment for Neonatal Opioid Withdrawal Syndrome (NOWS).
Funding Opportunity RFA-HD-21-032 from the NIH Guide for Grants and Contracts. This FOA invites applications for a Data Coordinating Center (DCC) to design and implement a multi-center, comparative effectiveness, randomized controlled trial (RCT) to assess the optimal pharmacological treatment for Neonatal Opioid Withdrawal Syndrome (NOWS).
Funding Opportunity RFA-AG-21-033 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites innovative research focused on understanding the regulation of brain regional and cell-type-specific proteome dynamics in Alzheimers disease (AD). Specifically, this FOA encourages collaborative approaches to design and implement novel, single-cell-based proteomic platforms to comprehensively characterize the dynamics of neuronal proteomes during the course of aging and AD.
Notice NOT-HG-21-021 from the NIH Guide for Grants and Contracts
Notice NOT-TW-21-001 from the NIH Guide for Grants and Contracts
Notice NOT-MD-21-011 from the NIH Guide for Grants and Contracts
Notice NOT-MD-21-010 from the NIH Guide for Grants and Contracts
Notice NOT-GM-21-001 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-21-089 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement is to provide continuing support for specific pathogen-free (SPF) macaque colonies previously funded under the auspices of PAR-18-669 and PAR-14-066. Breeding colonies are essential to sustain appropriate macaques for research related to Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS). Pedigree SPF macaques are free of certain viruses, which may confound the results of HIV/AIDS-related investigations or present a risk to the personnel who care for the animals. The SPF macaques are genetically characterized for major histocompatibility complex (MHC) class I types, because MHC class I genotypes have large effects on macaque immune responses to Simian Immunodeficiency Virus (SIV, which can induce AIDS in nonhuman primates (NHP)) and on human immune responses to HIV.
Funding Opportunity PAS-21-031 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks to stimulate HIV/AIDS research within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) that align with the HIV/AIDS research priorities outlined by the NIH Office of AIDS Research (OAR). These priorities were most recently described in NOT-OD-20-018 UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.
Funding Opportunity RFA-DK-20-508 from the NIH Guide for Grants and Contracts. Type 1 diabetes (T1D) is a serious and burdensome chronic disease that usually onsets in childhood or early adulthood. Recent progress in clinical trials and understanding of T1D pathogenesis and mechanisms have created opportunities to delay the onset and progression of the disease. This supplement is intended to provide resources for the design and conduct of new intervention studies in individuals at early pre-clinical stages of T1D and in individuals with new-onset T1D through the T1D TrialNet network (TrialNet). This Funding Opportunity Announcement (FOA) invites an application from the Program Director/Principal Investigator of the TrialNet Coordinating Center (TNCC) that is currently supporting the research being performed by TrialNet. The TNCC provides TrialNet with scientific leadership in study design and monitoring, supports the clinical and laboratory testing for the conduct of trials, and supports systems for data collection, processing, biostatistical analyses and administrative operations.
Funding Opportunity RFA-AI-21-001 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit meritorious applications for the Tuberculosis Research Advancement Centers (TRACs) program. The main goal of these centers is to provide administrative and shared research support to foster and elevate multidisciplinary tuberculosis (TB) research and provide exceptional mentorship to New Investigators. TRACs will provide core facilities, services and mentoring opportunities to achieve the goals of the program.
Funding Opportunity RFA-RM-21-010 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) invites applications for the Consortium Organization and Data Coordinating Center (CODCC) of the Cellular Senescence Network (SenNet) consortium. The goal of SenNet is to identify and functionally characterize the heterogeneity of senescent cells across multiple tissues in human health, and lifespan at single-cell resolution. The CODCC will serve as the organizational hub for SenNet collecting, storing, curating, and disseminating all data, metadata, analysis and visualization tools, computational models, and aggregate data across the Network into a searchable Atlas of Cellular Senescence; ensure the utility of the database; and promote collaboration through Network engagement with the research community.
Funding Opportunity RFA-RM-21-009 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement is to solicit novel analytics and technologies to identify senescent cells in human tissues This FOA supports the accelerated proof-of-principle demonstration and validation of promising tools, techniques and methods that can be integrated, scaled and applied to multiple human tissues. The initial two-year UG3 phase will support the development and demonstration of feasibility of these emerging technologies in the identification and mapping of senescent cells in mammalian tissues. The subsequent UH3 phase is to support initial validation in human tissues, optimization and scale-up, and generation of production level data. Investigators responding to this FOA must submit both UG3 and UH3 projects as part of a single application. UG3 projects that have met their quantifiable milestones will be administratively considered by NIH staff and prioritized for transition to the UH3 phase, depending on the availability of funds.
Funding Opportunity RFA-RM-21-008 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to establish state-of-the-art Tissue Mapping Centers (TMCs) to work within the Cellular Senescence Network (SenNet). The goal of the SenNet consortium is to identify and functionally characterize the heterogeneity of senescent cells across multiple tissues in human health, disease, and lifespan at single-cell resolution. Through collaborative efforts, the consortium will generate a multimodal, multidimensional Atlas of senescent cells in various human tissues; develop innovative tools and technologies to identify and characterize senescent cells; and aggregate data across the Network into a searchable Atlas of Cellular Senescence, ensure the utility of the database, and promote collaboration through Network engagement with the research community. The TMCs solicited through this RFA will generate the high-resolution, high-content, multiscale biomarkers and maps of cellular senescence across the lifespan and physiological states necessary to generate the Senescence Atlas. The SenNet is focused on healthy human tissues, and work in diseased tissue or animal models is acceptable only as long as it is used to support this overall goal. TMCs will be expected to integrate and optimize all parts of the data generation pipeline, from tissue collection and preservation through analyses at organ, tissue and single cell level using omics, imaging and other approaches, to data integration, analysis and interpretation.