NIH Weekly Funding Opportunities and Policy Notices
Funding Opportunity RFA-AG-22-019 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) will use the R01 funding mechanism to support discrete, specified, and circumscribed projects on novel molecular imaging approaches to establish high-resolution mapping of biomolecules in brain cells and regions during the course of aging and Alzheimers disease (AD).
Notice NOT-MH-21-305 from the NIH Guide for Grants and Contracts
Notice NOT-NS-21-074 from the NIH Guide for Grants and Contracts
Notice NOT-NS-21-075 from the NIH Guide for Grants and Contracts
Notice NOT-GM-21-052 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-RM-21-023 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) is associated with the NIH Common Fund Bridge2AI Program which seeks to generate flagship data sets and best practices for the collection and preparation of AI/ML-ready data to address biomedical and behavioral research grand challenges. The purpose of this FOA is to support an integration, dissemination and evaluation center which will integrate activities across Bridge2AI Data Generation Projects to develop cross-cutting products and best-practices. This FOA invites cooperative agreement applications to develop a BRIDGE Center that will be responsible for integrating activities and knowledge across Data Generation Projects, disseminating products, best-practices, and skill development materials/activities, and evaluating all aspects of the Bridge2AI program with input from external stakeholder communities. The BRIDGE Center will combine cores of expertise in administration, team science, ethics, standards, tools optimization, and skills and workforce development.
Funding Opportunity RFA-NS-21-027 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
Funding Opportunity RFA-NS-21-026 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
Funding Opportunity RFA-NS-21-029 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-21-016: The goal of this funding opportunity announcement (FOA) is to solicit Initial Analgesic Development R61 applications that propose 2-year exploratory/planning awards that are expected to enable a future application for RFA-NS-21-015 HEAL Initiative: Team Research - for Initial Translational Efforts in Non-addictive Analgesic Development [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed). Thus, the limited scope of aims and approach of these applications are expected to establish a strong research team, feasibility, validity, or other technically qualifying results that support, enable, and/or lay the groundwork for a subsequent Team Research U19 application. These R61 awards will support the building of a research team to collect initial data and recruit additional collaborators. The proposal must include a plan for developing a strong research team, as well as a strategy to collect preliminary data linking putative therapeutic targets to the proposed pain indication and supporting the hypothesis that altering target activity will produce desirable outcomes for the disease.
Notice NOT-HD-21-036 from the NIH Guide for Grants and Contracts
Notice NOT-NR-21-004 from the NIH Guide for Grants and Contracts
Notice NOT-ES-21-008 from the NIH Guide for Grants and Contracts
Notice NOT-NS-21-072 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-21-138 from the NIH Guide for Grants and Contracts. The National Cancer Institute (NCI) Method to Extend Research in Time (MERIT) (R37) Award provides extended grant support to Early Stage Investigators (ESIs). By providing such an opportunity for longer term support to ESIs, the NCI intends to offer flexibility and opportunity for creativity and innovation and additional time to successfully launch their careers and to become more established before having to submit renewal applications (NOT-CA-18-037). The objective of the NCI's ESI MERIT Award is to allow eligible investigators the opportunity to obtain up to 7 years of support in two segments:
Notice NOT-OD-21-138 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-RM-21-017 from the NIH Guide for Grants and Contracts. The NIH Directors Transformative Research Award Program supports individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. For the program to support the best possible researchers and research, applications are sought which reflect the full diversity of the research workforce. Individuals from diverse backgrounds and from the full spectrum of eligible institutions in all geographic locations are strongly encouraged to apply to this Funding Opportunity Announcement. In addition, applications in all topics relevant to the broad mission of NIH are welcome, including, but not limited to, topics in the behavioral, social, biomedical, applied, and formal sciences and topics that may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Directors Transformative Research Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.
Funding Opportunity RFA-DA-22-016 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support research project applications that are developmental and exploratory in nature to expand our knowledge on the basic neurobiology of the interrelationship between sleep and substance use disorders (SUDs). These mechanistic studies will not only offer an insight into the fundamental processes that link substance use disorders to disorders of sleep regulation and vice-versa but may also have implications for managing risk for the development of SUDs and identifying new targets for prevention and therapeutics.
Notice NOT-OD-21-130 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AA-21-009 from the NIH Guide for Grants and Contracts. This limited competition Funding Opportunity Announcement (FOA) is to support the continuation of the Data Analysis Resource for the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). Only the current NCANDA Data Analysis Resource awardee is eligible to apply in response to this FOA. The NCANDA Data Analysis Resource has responsibility for the standardization, storage, and analysis of the data acquired by the research project sites of the nation-wide consortium to study the impact of alcohol drinking on brain structure and function during adolescence and into early adulthood.
Funding Opportunity RFA-AA-21-007 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) is a limited competition to support the continuation of the Research Project Sites of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA). Only the current NCANDA Research Project Site awardees are eligible to apply in response to this FOA. The NCANDA Research Project Sites have responsibility for the acquisition of data according to the standard protocol for the nation-wide consortium to study the impact of alcohol drinking on brain structure and function during adolescence and into early adulthood. RFA-AA-21 NNN (FOA link) will support continuation of the NCANDA Administrative Resource and RFA-AA-21-NNN (FOA link) will support the continuation of the Data Analysis Resource.