NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-AG-23-009 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AI-23-019 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications from single institutions or consortia of institutions to participate in the Research and Development of Vaccines and Monoclonal Antibodies for Pandemic Preparedness (ReVAMPP) Network. The purpose of this FOA is to establish comprehensive, cooperative basic and translational research Centers to carry out in-depth research on prototype members of select virus families that have the potential to emerge as pandemic pathogens. The goal of these Centers will be to develop vaccine and monoclonal antibody strategies for prototype pathogen(s) that can be applied to closely related family members based on shared functional and structural properties. This FOA solicits for Centers proposing research on virus families from Flaviviridae and Togaviridae to be part of the ReVAMPP Network.
Funding Opportunity RFA-AI-23-020 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications from single institutions or consortia of institutions to participate in the Research and Development of Vaccines and Monoclonal Antibodies for Pandemic Preparedness (ReVAMPP) Network. The purpose of this FOA is to establish comprehensive, cooperative basic and translational research Centers to carry out in-depth research on prototype members of select virus families that have the potential to emerge as pandemic pathogens. The goal of these Centers will be to develop vaccine and monoclonal antibody strategies for prototype pathogen(s) that can be applied to closely related family members based on shared functional and structural properties. This FOA solicits for centers proposing research on virus families from Bunyavirales, Paramyxoviridae and Picornaviridae to be part of the ReVAMPP Network.
Funding Opportunity RFA-AI-23-021 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications from single institutions or consortia of institutions to establish a Coordination and Data Sharing Center (CDSC) in support of the Research and Development of Vaccines and Monoclonal Antibodies for Pandemic Preparedness (ReVAMPP) Centers. Together, the CDSC and ReVAMPP Centers will form the ReVAMPP Network. The purpose of the CDSC is to support, coordinate, and manage ongoing and planned activities within the ReVAMPP Network. The CDSC is expected to establish and maintain a collaborative ReVAMPP Network platform for data sharing as needed to harmonize reagents, assays, animal models and exchange knowledge on structure/function-based vaccine solutions and antigen/immunogen design as well as assess the utility of vaccine technology platforms for virus families studied under the ReVAMPP Centers. The CDSC is also expected to facilitate effective communications across the ReVAMPP Centers by scheduling, and managing all meetings, tracking overall network progress and outputs, developing opportunities for collaboration among the Centers such as establishing working groups, and under the direction of NIAID, collating information and facilitating exchange with other NIAID/NIH programs, U.S. Government (USG)partners, and other key stakeholders, including the World Health Organization (WHO), Bill and Melinda Gates Foundation (BMGF), and Coalition for Epidemic Preparedness Innovations (CEPI) among others as appropriate.
Funding Opportunity PAR-23-123 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a diverse workforce, which includes individuals from backgrounds that are not well represented in biomedical research (see NIH Interest in Diversity: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-20-031.html), to meet the nations biomedical, behavioral and clinical research needs. To accomplish the stated over-arching goal, this FOA will support creative educational activities with a primary focus on Courses for Skills Development. The purpose of this PAR is twofold: 1) develop, implement, and evaluate modules of genomics-related curriculum for the diverse entry-level biomedical research workforce by supporting lead sites teamed with partner sites, such as community, technical, or tribal colleges; and 2) support and facilitate opportunities for the entry-level research workforce to enhance diversity in genomics. The training modules will be made freely available, at no cost to the broader community.
Notice NOT-AG-23-002 from the NIH Guide for Grants and Contracts
Notice NOT-ES-23-007 from the NIH Guide for Grants and Contracts
Notice NOT-CA-23-050 from the NIH Guide for Grants and Contracts
Notice NOT-AG-23-012 from the NIH Guide for Grants and Contracts
Notice NOT-MH-23-210 from the NIH Guide for Grants and Contracts
Notice NOT-GM-23-034 from the NIH Guide for Grants and Contracts
Notice NOT-HL-23-078 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AG-24-010 from the NIH Guide for Grants and Contracts. The purpose of this limited competition FOA is to solicit an application to continue data collection, development, and dissemination of the Health and Retirement Study (HRS). The HRS is a longitudinal panel study that surveys a nationally representative sample of approximately 20,000 people aged 50 and older in the United States via mixed-mode data collection to support multidisciplinary research on life course health and aging. This renewal provides additional research opportunities to use HRS to study Alzheimers Disease and Related Dementias (AD/ADRD) formally including a companion project, the Harmonized Cognitive Assessment Protocol (HCAP), that included a neuropsychological assessment battery as well as informant reports to better characterize cognitive function. This single integrated award combining HRS and HCAP will also add important additions recommended by subject matter experts to enhance HRS/HCAP to facilitate research on AD/ADRD: additions of larger samples of Black and Hispanic populations in HCAP; contextual data to capture new elements of the exposome ranging from microscopic to macro level exposures; improving overall response/retention rates to maintain representativeness; enhanced data on occupational exposures/characteristics; expanded aging and AD/ADRD-relevant blood-based biomarkers; additional content on social factors to study racial disparities and minority health via life histories as well as the medium and long-term social impacts of the COVID-19 pandemic.
Funding Opportunity RFA-AG-24-004 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) invites U01 applications to develop national cost of illness estimates for the monetary cost of Alzheimers Disease and Alzheimers disease-related dementias (AD/ADRD) in the United States using a societal perspective. The purpose of this FOA is to support development of a national estimate of the costs of AD/ADRD using population-representative and administrative data on older Americans through a comprehensive process that uses a family and People Living With Dementia engagement panel and a Technical Monitoring Committee. Applicants must describe administrative and convening activities - including a Family and People Living With Dementia engagement panel and a Technical Monitoring Committee - to guide cost estimate development and analyses. The awardee under this FOA must establish access to appropriate dataset(s) through NIAs data linkage support contract (MedRIC.info) and analyze the data to develop estimates of costs, including direct and indirect costs. Once data have been analyzed, the awardee will lead development of products to disseminate the methods and findings of the project, through the composition of manuscripts, data briefs, infographics, and presenting the findings of the project to the scientific community. The awardee will administer pilot projects to support cost simulations assessing treatment and policy changes that would alter the cost of disease. Analytic code and products of this work will be shared with the research community.
Notice NOT-GM-23-037 from the NIH Guide for Grants and Contracts
Notice NOT-RM-23-008 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-EB-23-002 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to
Funding Opportunity RFA-NS-24-004 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
Funding Opportunity RFA-NS-24-005 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.
Blood Brain Barrier Response to Antibodies Targeting Beta-Amyloid (R01 - Clinical Trial Not Allowed)
Funding Opportunity PAR-23-140 from the NIH Guide for Grants and Contracts. This initiative is designed to promote discovery of cellular and molecular mechanisms that underlie brain blood vessels responses to passive anti-beta-amyloid immunotherapy that result in amyloid-related imaging abnormalities (ARIA). The goal is to establish an understanding of molecular mechanisms that can be targeted to protect the blood brain barrier (BBB), and thus the brain blood vessels, during therapeutic interventions that target beta-amyloid.