NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-MH-17-003 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AG-17-063 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks to promote the development of an interdisciplinary workforce to conduct research on Alzheimer's disease and Alzheimer's disease related dementias. This FOA will support institutional training programs for predoctoral and postdoctoral level researchers with backgrounds in biology, data sciences and traditional and emerging pharmaceutical science. The program will provide trainees with the knowledge and skills to participate in a team-based approach to solving data-intensive biomedical problems in basic research and therapy development for Alzheimer's disease and Alzheimer's disease related dementias.
Funding Opportunity RFA-DK-16-505 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites an application from the Program Director/Principal Investigator of the Data Coordinating Center (DCC) that is currently supporting the research being performed by the complex and effective Type 1 Diabetes TrialNet network. This FOA will support the design and conduct of new-onset trials (as selected by the TrialNet Steering Committee) aimed at preservation of insulin-producing cells in individuals with new-onset diabetes. The DCC will support a wide range of research projects in varying stages of development, implementation and completion. The DCC will provide for data and sample management, including standardized acquisition, quality control, dissemination, and public accessibility.
Funding Opportunity PAR-17-066 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to NIA's Small Business Technology Transfer (STTR)) program for research focusing on the development of innovative technologies in the clinical care and management of Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD).
Funding Opportunity PAR-17-067 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to NIA's Small Business Innovation Research (SBIR) program for research focusing on the development of innovative technologies in the clinical care and management of Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD).
Funding Opportunity RFA-NS-17-016 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to invite research applications proposing to investigate the clinical, imaging, or physiological characteristics of subjects with dementia and parkinsonism (Lewy Body Dementia) using previously-collected data available in the Alzheimers Disease Neuroimaging Initiative (ADNI)/National Alzheimer's Coordinating Center (NACC) and/or the Parkinsons Disease Biomarker Program (PDBP) databases. Research should focus on identifying clinical or biological attributes that could serve to 1) lead to early diagnosis, 2) improve differential diagnosis, and/or 3) lead to the identification of potential therapeutic targets. Applicants must propose to use data in at least one of the ADNI or PDBP databases, but may include the use of other previously-collected data if such data is scientifically relevant and of comparable quality. Applicants are not expected or encouraged to collect new data.
Funding Opportunity PAS-17-065 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to NIA's Small Business Technology Transfer Research (STTR)program to conduct research leading to the development of innovative products and/or services that may advance progress in preventing and treating Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD) and/or caring for and treating AD/ADRD patients.
Funding Opportunity PAS-17-064 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages applications to NIA's Small Business Innovation Research (SBIR) program to conduct research leading to the development of innovative products and/or services that may advance progress in preventing and treating Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD) and/or caring for and treating AD/ADRD patients.
Funding Opportunity RFA-NS-17-014 from the NIH Guide for Grants and Contracts. This FOA solicits applications for research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity. Projects can use non-human animal species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.
Funding Opportunity RFA-NS-17-015 from the NIH Guide for Grants and Contracts. This FOA solicits applications for exploratory research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. Applications should offer a limited scope of aims and an approach that will establish feasibility, validity or other technically qualifying results that, if successful, would support a potential, subsequent Targeted Brain Circuits Projects - TargetedBCP R01, as described in the companion FOA (RFA-NS-17-014).
Funding Opportunity RFA-NS-17-018 from the NIH Guide for Grants and Contracts. This FOA will support integrated, interdisciplinary research teams from prior BRAIN technology and/or integrated approaches teams, and/or new projects from the research community that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one competing renewal. Applications should address overarching principles of circuit function in the context of specific neural systems underlying sensation, perception, emotion, motivation, cognition, decision-making, motor control, communication, or homeostasis. Applications should incorporate theory-/model-driven experimental design and should offer predictive models as deliverables. Applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework that will be developed and used in the proposed U19 project and exchanged with other U19 awardees for further refinement and development. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Budgets should be commensurate with multi-component teams of research expertise including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate - that seek to cross boundaries of interdisciplinary collaboration.
Funding Opportunity PAR-17-063 from the NIH Guide for Grants and Contracts. As part of the Gabriella Miller Kids First Pediatric Research Program (Kids First), the NIH invites applications to use whole genome sequencing at a Kids First-supported sequencing center. Applicants are encouraged to propose sequencing of existing pediatric cancer cohorts to elucidate the genetic contribution to childhood cancers, or to expand the range of disorders included within the Kids First Data Resource to investigate the genetic etiology of structural birth defects. These data will become part of the Gabriella Miller Kids First Pediatric Data Resource (Kids First Data Resource) for the pediatric research community.
Notice NOT-OD-17-024 from the NIH Guide for Grants and Contracts
Notice NOT-HL-16-465 from the NIH Guide for Grants and Contracts
Notice NOT-HL-16-478 from the NIH Guide for Grants and Contracts
Notice NOT-HD-16-035 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-NS-17-019 from the NIH Guide for Grants and Contracts. Invasive surgical procedures provide the unique ability to record and stimulate neurons within precisely localized brain structures in humans. Human studies using invasive technology are often constrained by a limited number of patients and resources available to implement complex experimental protocols and are rarely aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this FOA seeks applications to assemble integrated, multi-disciplinary teams to overcome these fundamental barriers. Projects should investigate high-impact questions in human neuroscience and disorders of the human nervous system. The research should be offered as experimental projects, or exploratory research and planning activities, for building teams, generating data and empirical results that will later compete for continued funding under new or ongoing FOAs of the BRAIN Initiative or under NIH Institute appropriations.
Funding Opportunity RFA-DK-16-506 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to complete treatment of the participants recruited into the Preventing Early Renal Loss in Diabetes (PERL) Study and to analyze the outcomes of the trial. PERL is a randomized, double-blind trial to test whether the medication, allopurinol, can slow the progression of kidney disease in people with type 1 diabetes and early diabetic kidney disease.
Funding Opportunity RFA-DK-17-001 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications for Silvio O. Conte Digestive Diseases Research Core Centers (DDRCCs). The DDRCCs are part of an integrated program of digestive and liver diseases research support provided by the NIDDK. The purpose of this Centers program is to bring together basic and clinical investigators as a means to enhance communication, collaboration, and effectiveness of ongoing research related to digestive and/or liver diseases. DDRCCs are based on the core concept, whereby shared resources aimed at fostering productivity, synergy, and new research ideas among the funded investigators are supported in a cost-effective manner. Each proposed DDRCC must be organized around a central theme that reflects the focus of the digestive or liver diseases research of the Center members. The central theme must be within the primary mission of NIDDK, and not thematic areas for which other NIH Institutes or Centers are considered the primary source of NIH funding.
Funding Opportunity PA-17-060 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to encourage research grant applications to: (1) assess and describe the current state of oral anticancer medication utilization, delivery, and adherence; (2) identify structural, systemic, and psychosocial barriers to adherence; and (3) develop models and strategies to improve safe and effective delivery of these agents so that clinical outcomes are optimized. Applications should focus research questions on at least one of the following: specific cancer type; class of drugs; and/or groups subject to disparities (e.g., elderly populations, members of low socioeconomic groups, racial/ethnic minorities). Research may be focused at the patient (pediatric, adolescent, or adult), patient-caregiver, provider, health care team, or health care delivery system level, and may include intervention studies, observational studies, or mixed-methods studies. Observational studies should emphasize modifiable risk factors for future intervention research.