NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-CA-23-089 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-MH-25-145 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity announcement (NOFO) supports systematic and scalable approaches to profile the biological function of genes with an excess of damaging mutations in patients with neurodevelopmental and psychiatric disorders. Current understanding of the relationship between genetic and phenotypic variation is limited and one of the main bottlenecks in translating disease-associated genes to biology lies in the lack of scalable experimental platforms that can extend the unbiased nature of gene discovery to the discovery of biological mechanisms. This concept will attempt to fill that gap while also providing a bridge between existing NIMH efforts such as PsychENCODE and Convergent Neuroscience. New technologies and approaches are now making it possible to systematically implement high-throughput assays to determine how disease-linked genetic variation impacts neural function across biological levels of organization. This initiative proposes a series of NOFOs to support the large-scale implementation of high-throughput assays to interrogate the molecular, cellular and physiological function of hundreds of disease-associated genes in parallel. A combination of full-scale and pilot projects will form a consortium for broad characterization of risk genes across an array of endpoints relevant to CNS function using a variety of experimental platforms (e.g., cellular, organismal). A consortium coordination center (CCC) will serve as a central hub providing administrative coordination across projects, including data and tools harmonization, development of an open-source portal to create a unified dataset and creating a standardized set of biological resources for use by the research community.
Notice NOT-MD-23-018 from the NIH Guide for Grants and Contracts
Notice NOT-NS-24-011 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DE-24-003 from the NIH Guide for Grants and Contracts. The objective of this Notice of Funding Opportunity (NOFO) is tosupport highly integrated research teams to address challenging questions with the potential to significantly advance dental, oral and craniofacial (DOC) fields of research. Each project should have a unified and well-defined scientific goal within the NIDCR mission that requires a team with diverse perspectives and expertise in a variety of intellectual or technical areas and is beyond the experience and capabilities of one or two investigators. Collaborative program teams are expected to accomplish goals that require considerable synergy and managed team interactions.
Notice NOT-NS-24-009 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-23-257 from the NIH Guide for Grants and Contracts. The purpose of the IDeA-CTR initiative is to expand the capacity for clinical and translational research in IDeA-eligible states/jurisdictions and to enhance the competitiveness of the investigators to obtain extramural funding for clinical and translational research. This Funding Opportunity Announcement (FOA) provides cooperative agreement support for statewide and/or interstate regional networks to achieve the following objectives: (1) to support the development and/or enhancement of infrastructure and human resources required to address clinical and translational research needs in IDeA-eligible states/jurisdictions, (2) to strengthen clinical and translational research that addresses the broad spectrum of health challenges faced by populations in IDeA-eligible states/jurisdictions, and (3) to foster and coordinate collaboration in clinical and translational research within an IDeA-CTR network and with other institutions.
Funding Opportunity PAR-23-241 from the NIH Guide for Grants and Contracts. The purpose of the IDeA-CTR initiative is to expand the capacity for clinical and translational research in IDeA-eligible states/jurisdictions and to enhance the competitiveness of the investigators to obtain extramural funding for clinical and translational research. This Funding Opportunity Announcement (FOA) provides cooperative agreement support for statewide and/or interstate regional networks to achieve the following objectives: (1) to support the development and/or enhancement of infrastructure and human resources required to address clinical and translational research needs in IDeA-eligible states/jurisdictions, (2) to strengthen clinical and translational research that addresses the broad spectrum of health challenges faced by populations in IDeA-eligible states/jurisdictions, and (3) to foster and coordinate collaboration in clinical and translational research within an IDeA-CTR network and with other institutions.
Funding Opportunity RFA-HG-23-002 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (UE5) supports research education activities in the mission areas of the NIH. The overarching goal of this UE5 program is to support educational activities that encourage individuals from diverse backgrounds, including those from groups underrepresented in the biomedical and behavioral sciences, to pursue further studies or careers in computational genomics and data science research. To accomplish the stated over-arching goal, this NOFO will support creative educational activities with a primary focus on: Courses for Skills Development Specifically, this UE5 program will support faculty members at minority-serving institutions (MSIs) to create undergraduate or masters degree courses in computational genomics, data science, or a combination of these topics. Support for this activity will be provided by the Educational Hub for Enhancing Diversity in Computational Genomics and Data Science, created through RFA-HG-22-002. For developing skills in computational genomics and data science, these courses will leverage the resources of NIH cloud computing platforms such as NHGRIs AnVIL and the All of Us Researcher Workbench.
Funding Opportunity PAR-22-268 from the NIH Guide for Grants and Contracts. The purpose of this Notice is to alert the community that NHGRI plans to publish a Funding Opportunity Announcement (FOA) to transform NHGRIs Diversity Action Plan (R25 Clinical Trials Not Allowed) to better align with more recent NHGRI and NIH-wide efforts to increase workforce diversity. Individuals from diverse backgrounds are needed to address research challenges and opportunities in genome sciences, genomic medicine, genomics and society, data science, and health equity research. To build on the remarkable metamorphosis of the field of genomics over the last three decades, enhancing the diversity of the genomics workforce must be embraced as an urgent priority. Toward that end, NHGRI recently developed an action agenda for training, employing, and retaining a genomics workforce that reflects the diversity of the US population. Relevant to its training and career development portfolio, NHGRI is committed to supporting pathways that help diverse groups of individuals develop the skills and knowledge to pursue a career in genomics. Recent strategic planning undertaken at NHGRI underscores this commitment, as described in the 2020 NHGRI Strategic Vision, the NHGRI Action Agenda for Building a Diverse Genomic Research Workforce, and the NHGRI Training Task Force Report presented to the National Advisory Council for Human Genome Research in February, 2020.
Funding Opportunity RFA-DE-24-005 from the NIH Guide for Grants and Contracts. This FOA will encourage interdisciplinary research that harnesses the functional components of saliva towards therapeutics. It is expected that outcomes will facilitate development of highly effective surrogate saliva for clinical applications.
Funding Opportunity RFA-DE-24-004 from the NIH Guide for Grants and Contracts. This FOA will encourage interdisciplinary research that harnesses the functional components of saliva towards therapeutics. It is expected that outcomes will facilitate development of highly effective surrogate saliva for clinical applications.
Funding Opportunity RFA-MH-24-235 from the NIH Guide for Grants and Contracts. HIV associated CNS complications are a significant problem for people living with HIV despite suppressive anti-retroviral therapy. HIV enters the CNS as early as 8 days after infection and can cause several complications including cognitive, neurological and mental health related issues. Although experts have gathered much data on underlying HIV-induced CNS pathophysiology, specific targeted causality remains elusive, and no effective therapies exist to slow, stop, or reverse these adverse outcomes. This initiative is to comprehend the actionable biotypes of CNS complications in people living with HIV based on underlying mechanisms to help capture the heterogeneity of outcomes. Identifying biotypes can inform the development of precision treatment strategies for CNS complications seen in people living with HIV.
Funding Opportunity RFA-AG-24-031 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for R01 research projects that aim to advance economic research on Alzheimers disease (AD) and AD-related dementias (ADRD) by examining the development and diffusion of treatment/care innovations, payment and treatment models for care and care access for people living with dementia (PLWD) and their caregivers, and?economic factors influencing disease progression addressing AD/ADRD research implementation milestones?1.P,?13.P,?13.M, and?13.N. These projects will be linked to the Consortium for Economic Research on AD/ADRD Prevention, Treatment and Care Coordination Center (RFA-AG-24-030) to foster collaboration and synergies across consortium member projects. Investigators will work with the?Coordinating Center to ?share resources used in proposed research both within the consortium as well as with others for health research purposes.??
Funding Opportunity RFA-AG-24-030 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for a U54 Specialized Center to advance economic research on Alzheimers disease (AD) and AD-related dementias (ADRD) by supporting a consortium of research projects examining the development and diffusion of treatment/care innovations, payment and treatment models for care, care quality and access for people living with dementia (PLWD) and their caregivers, as well as economic factors influencing disease progression to address NIA AD/ADRD research implementation milestones1.P,13.P,13.M, and13.N fromRFA-AG-24-031. The Center will foster collaboration and synergies across consortium member research projects, initiate new research projects, expand the network of researchers studying the economics of AD/ADRD, and disseminate findings to key stakeholders to support policymaking.
Notice NOT-RM-23-023 from the NIH Guide for Grants and Contracts
Notice NOT-DA-24-012 from the NIH Guide for Grants and Contracts
Notice NOT-OD-23-167 from the NIH Guide for Grants and Contracts
Notice NOT-OD-23-166 from the NIH Guide for Grants and Contracts
Notice NOT-OD-23-165 from the NIH Guide for Grants and Contracts