NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-GM-23-025 from the NIH Guide for Grants and Contracts
Notice NOT-OD-23-039 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-DA-24-014 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support basic research on signaling pathways and mechanisms including HIV-host protein interactions and post-translational modifications by which addictive drugs and HIV infection converge to induce changes in brain function and cause neuropathological alterations and neurocognitive dysfunctions. This FOA also aims to promote discovery and development of novel chemical and biological approaches for prevention or mitigation of CNS complications associated with HIV infection and substance use disorders.
Funding Opportunity RFA-DA-24-013 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support basic research on signaling pathways and mechanisms including HIV-host protein interactions and post-translational modifications by which addictive drugs and HIV infection converge to induce changes in brain function and cause neuropathological alterations and neurocognitive dysfunctions. This FOA also aims to promote discovery and development of novel chemical and biological approaches for prevention or mitigation of CNS complications associated with HIV infection and substance use disorders.
Notice NOT-AT-23-006 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AT-23-009 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support a collection of research networks that promote multidisciplinary mechanistic studies of music-based interventions (MBIs) for pain or Alzheimers disease and Alzheimers disease-related dementias (AD/ADRD). These networks are expected to develop compelling research frameworks that will effectively guide future clinical studieson MBIs in these health conditions; adopt consistent terminology and taxonomy; support interdisciplinary collaborations andinitiate pilot projects to test novel mechanistic hypotheses; and identify strong mechanistic measures, outcomes, biomarkers, as well as relevant novel technologies and methodologies. To accomplish these objectives, applicants can propose activities such as meetings, workshops, conferences, research collaborations, exchange of ideas through visiting scientist arrangements or training opportunities. These activities will help identify unique research gaps that can be addressed through the networks in the form of pilot projects which will in turn generate the preliminary data needed for music and health investigators to compete for more substantial NIH grants. In addition, the networks shall sustain their scientific impact through a variety of dissemination and outreach strategies, including publication of research frameworks, common terminologies, reviews, and other best practices.
Funding Opportunity RFA-DA-24-012 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support effectiveness research to test interventions or services that prevent opioid misuse or opioid use disorder specifically among youth, caregivers (including foster parents), and families served by the child welfare system. The goal of this research is to grow the body of evidence-based prevention programs effective for use within or through referrals from the child welfare system, ultimately reducing immediate and multigenerational risk for substance misuse among families. In this initiative, involvement with the child welfare system is defined broadly to include populations with risk for entering, currently receiving services from, or having exited from the child welfare system.
Funding Opportunity RFA-DA-24-011 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support effectiveness research to test interventions or services that prevent opioid misuse or opioid use disorder specifically among youth, caregivers (including foster parents), and families served by the child welfare system. The goal of this research is to grow the body of evidence-based prevention programs effective for use within or through referrals from the child welfare system, ultimately reducing immediate and multigenerational risk for substance misuse among families. In this initiative, involvement with the child welfare system is defined broadly to include populations with risk for entering, currently receiving services from, or having exited from the child welfare system.
Funding Opportunity RFA-NS-23-010 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA), issued by NINDS, is to invite currently awarded NIH StrokeNet centers and potential new stroke centers to participate as a Regional Coordinating Stroke Center (RCC) in the NIH StrokeNet clinical trials network. Established by NINDS in 2013, the goal of the NIH StrokeNet is to harness the leadership and experience of the stroke research field to maximize efficiencies for developing, promoting and conducting high-quality, multi-site clinical trials focused on promising interventions for stroke prevention, treatment, and recovery with the objective of having a balanced portfolio between all three approaches. Multi-site exploratory and confirmatory Phase 3 clinical trials as well as biomarker-validation studies that are immediately preparatory to trials and ancillary studies designed to add scientific aims to active studies will be coordinated through separate National Coordinating (NCC) and National Data Management Centers (NDMC). Funded RCC's in the network will be regional academic medical centers that include geographically or organizationally linked partners, clinical performance sites or satellite stroke centers that are committed to randomizing patients in NINDS-funded NIH StrokeNet clinical studies. RCC's will have both clinical science excellence and specialized expertise in stroke management, as well as a strong background in stroke research, and a proven ability to recruit stroke patients. Each RCC will also have strong collaborative relationships between vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology, thereby demonstating a commitment to offer all eligible patients the opportunity to participate in a trial conducted through the network. In addition, the NIH Stroke Trials Network will include an active stroke research career advancement program.
Funding Opportunity RFA-NS-23-009 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to invite applications to participate as the National Coordinating (NCC) Center for the NIH Stroke Trials Network.Established by NINDS in 2013, the goal of the NIH StrokeNet is to harness the leadership and experience of the stroke research field to maximize efficiencies for developing, promoting and conducting high-quality, multi-site clinical trials focused on promising interventions for stroke prevention, treatment, and recovery with the objective of having a balanced portfolio between all three approaches. Multi-site exploratory and confirmatory Phase 3 clinical trials as well as biomarker-validation studies that are immediately preparatory to trials and ancillary studies designed to add scientific aims to active studies will be coordinated through a National Coordinating (NCC) and National Data Management Centers (NDMC) and multiple regional coordinating stroke centers (RCC's) with strong collaborative relationships between vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology. The network will provide a robust, standardized, and accessible infrastructure to provide the development and implementation of protocols in in stroke prevention, treatment, and recovery. The NCC will provide leadership and overall network coordination to harness the clinical science excellence and specialized expertise in stroke management at the RCC's to facilitate the recruitment of stroke patients in multiple ongoing stroke trials and studies. This FOA solicits applications for the National Coordinating Center for the Stroke Trials Network. Separate FOAs solicit applications for the Regional Coordinating Stroke Centers and the National Data Management Center.
Funding Opportunity RFA-NS-23-008 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to invite applications to participate as the National Data Management Center (NDMC) for the NIH Stroke Trials Network. Established by NINDS in 2013, the goal of the NIH StrokeNet is to harness the leadership and experience of the stroke research field to maximize efficiencies for developing, promoting and conducting high-quality, multi-site clinical trials focused on promising interventions for stroke prevention, treatment, and recovery with the objective of having a balanced portfolio between all three approaches. Multi-site exploratory and confirmatory Phase 3 clinical trials as well as biomarker-validation studies that are immediately preparatory to trials and ancillary studies designed to add scientific aims to active studies will be coordinated through a National Coordinating (NCC) and National Data Management Centers (NDMC) and multiple regional coordinating stroke centers (RCC's) with strong collaborative relationships between vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology. The network will provide a robust, standardized, and accessible infrastructure to provide the development and implementation of protocols in stroke prevention, treatment, and recovery. The NDMC will be responsible for centralizing, harmonizing and coordinating all aspects of data collection for studies conducted in the network. Projects will be developed both from investigators both within the network as well as from investigators or industry partners outside of the network; therefore the data center for the stroke network must be able to efficiently collaborate with all parties. This FOA solicits applications for the National Data Management Center for the Stroke Trials Network. Separate FOAs solicit applications for the Regional Coordinating Stroke Centers and the National Coordinating Center.
Funding Opportunity RFA-NS-22-025 from the NIH Guide for Grants and Contracts. The purpose of the NIH HEAL InitiativeSM Pathway to Independence Award (K99/R00) program is to enhance workforce diversity in the research workforce and maintain a strong cohort of new and talented independent investigators conducting Pain and/or SUD research, in order to increase the pool of diverse and independent investigator workforce in research areas supported by the NIH HEAL InitiativeSM. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL InitiativeSM. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, an ancillary clinical trial, or an independent Basic Experimental Studies with Humans (BESH). Applicants to this FOA are permitted to propose research experience in a clinical trial led by a mentor or co-mentor. Applicants proposing an independent clinical trial, a clinical trial feasibility study, an ancillary clinical trial, or an independent BESH as lead investigator, should apply to the companion FOA (RFA-NS-22-024).
Funding Opportunity RFA-NS-22-024 from the NIH Guide for Grants and Contracts. The purpose of the NIH HEAL InitiativeSM Pathway to Independence Award (K99/R00) program is to enhance workforce diversity in the research workforce and maintain a strong cohort of new and talented independent investigators conducting Pain and/or SUD research, in order to increase the pool of diverse and independent investigator workforce in research areas supported by the NIH HEAL InitiativeSM. This program is designed to facilitate a timely transition of eligible postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL InitiativeSM. This Funding Opportunity Announcement (FOA) is designed specifically for applicants proposing research to serve as the lead investigator of an independent clinical trial, a clinical trial feasibility study, an ancillary clinical trial, or an independent Basic Experimental Studies with Humans (BESH). Applicants not planning an independent clinical trial, or proposing to gain research experience in a clinical trial led by another investigator, must apply to companion FOA (RFA-NS-22-025).
Funding Opportunity RFA-NS-22-023 from the NIH Guide for Grants and Contracts. The purpose of the NIH HEAL InitiativeSM Pathway to Independence Award (K99/R00) program is to support a cohort of new and talented independent investigators conducting Pain and/or SUD research, in order to increase the independent investigator workforce in research areas supported by the NIH HEAL InitiativeSM. This program is designed to facilitate a timely transition of eligible outstanding postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL InitiativeSM.
Funding Opportunity RFA-NS-22-022 from the NIH Guide for Grants and Contracts. The purpose of the NIH HEAL InitiativeSM Pathway to Independence Award (K99/R00) program is to support a cohort of new and talented independent investigators conducting Pain and/or SUD research, in order to increase the independent investigator workforce in research areas supported by the NIH HEAL InitiativeSM. This program is designed to facilitate a timely transition of eligible outstanding postdoctoral researchers from their mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition to help awardees establish independent research programs in areas supported by the NIH HEAL InitiativeSM.
Notice of Special Interest (NOSI) for Efficacy Trials of Epidural Stimulation for Spinal Cord Injury
Notice NOT-NS-23-038 from the NIH Guide for Grants and Contracts
Funding Opportunity RFA-AI-22-075 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to provide support to the 12 Regional Biocontainment Laboratories (RBLs) previously constructed with NIAID support to enable them to develop and maintain resources, staff, and facilities necessary to address biodefense agents, emerging infectious diseases, and pandemic preparedness in line with NIAID priorities. Operations support is provided for facility maintenance and operations, as well as Biosafety Level 3 (BSL-3) practices support for personnel working in and around BSL-3 space and associated building systems. An optional component would allow the RBLs to provide specialized services essential to support BSL3 activities. The RBLs will serve as regional resources for efforts in conducting pre-clinical and laboratory (in vitro and in vivo) research and testing on hazardous biological agents in support of NIAIDs biodefense, emerging infectious diseases, and pandemic preparedness research efforts.
Notice NOT-RM-22-019 from the NIH Guide for Grants and Contracts
Notice NOT-CA-23-024 from the NIH Guide for Grants and Contracts
Notice NOT-AG-22-049 from the NIH Guide for Grants and Contracts