NIH Weekly Funding Opportunities and Policy Notices
Notice NOT-AI-23-012 from the NIH Guide for Grants and Contracts
Notice NOT-AI-23-001 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-22-256 from the NIH Guide for Grants and Contracts. Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) intends to accelerate the development of evidence-based cancer-related interventions to improve health equity and reflect the diversity of people, places, contexts, and settings in the United States. Specifically, this FOA will support research that tests the impact of cancer-related interventions on cancer-related outcomes across the cancer control continuum using a pragmatic trial study design. This FOA will use the UG3/UH3 phased cooperative agreement mechanism. The UG3 phase will support refining the cancer-related intervention and finalizing study-related activities in preparation for conducting the pragmatic trial during the UH3 phase.
Funding Opportunity PAR-23-038 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support Testing Centers for Somatic Cell Genome Editing in specified major mammalian animal model species (rodents, pigs, and non-human primates). Each Center will provide resources and testing services to the growing community developing new genome editing technologies and conducting preclinical testing based upon these technologies for therapeutics of human diseases. The Testing Centers will work with NIH funded investigators to assess the efficacy and safety of in vivo genome editing and delivery technologies, determine genome editing thresholds for specific diseases associated with minimal off-target effects, and ascertain feasibility parameters in a model system. This data will be important in determining if a treatment strategy using a specific set of tools is effective and has an acceptable safety profile, or if the efficacy and specificity of editing should be significantly improved. Even though each Testing Center will work on a limited number of focused projects, it is expected that the program and pipeline(s) developed will maintain multifaceted research activities to build core model systems that can be adjusted as required to accommodate a broad spectrum of diseases as well as provide fee-for-service to the wider biomedical community on a national basis.
Funding Opportunity PAR-23-065 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA), issued by the National Institute of Allergy and Infectious Diseases (NIAID), invites applications for investigator-initiated Resource-Related Research Projects (R24). The proposed resource must provide a significant benefit to currently funded high priority projects in need of further coordination and support in the areas specified. Under rare circumstances, this mechanism may be used to support development of a new resource to the broader scientific community of the NIAID. It is anticipated that the request for resource support through the R24 activity code will occur on an infrequent basis and only in circumstances where other mechanisms of support from the NIAID are not appropriate. The proposed resources should be relevant to the scientific areas of the NIAID mission including the biology, pathogenesis, and host response to microbes, including HIV; the mechanisms of normal immune function and immune dysfunction resulting in autoimmunity, immunodeficiency, allergy, asthma, and transplant rejection; and translational research to develop vaccines, therapeutics, and diagnostics to prevent and treat infectious, immune-mediated, and allergic diseases.
Funding Opportunity RFA-HD-24-006 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to address the needs of the maternal and pediatric HIV scientific community for research data translation and sharing. This initiative will support secondary data analyses using archived HIV/AIDS data and specimens to generate new research questions and findings relevant to the scientific mission and priorities of the NICHD, Maternal and Pediatric Infectious Disease Branch (MPIDB) and Office of AIDS Research (OAR). The goal of this initiative is to encourage applicants to leverage existing datasets and employ new and advanced analysis techniques to answer scientific questions about the epidemiology, pathogenesis, treatment, clinical manifestations and complications of HIV/AIDS in maternal, pediatric and adolescent populations.
Funding Opportunity RFA-MH-23-310 from the NIH Guide for Grants and Contracts. The purpose of this Request for Applications (RFA) is to solicit research that will help to identify and explain the mechanisms and pathways by which interventions targeting social drivers of mental illnesses affect the mental health and functioning of children and/or adolescents (ages 5-24 years) living in World Bank designated low- and middle-income countries (LMICs) . Studies should use innovative approaches to capture as much real-world complexity as possible in identifying and elucidating mechanisms and pathways that reduce risk for mental illnesses or improve mental health in children and/or adolescents.
Funding Opportunity RFA-AI-22-067 from the NIH Guide for Grants and Contracts. This Funding opportunity Announcement (FOA) solicits applications for the International Centers of Excellence for Malaria Research (ICEMR) Program, a multidisciplinary network of centers that will conduct research in malaria-endemic sites to 1) improve our understanding of malaria pathogenesis, epidemiology, and transmission; and 2) evaluate, optimize, and inform development of interventions to understand, control, eliminate, and eventually eradicate malaria. This program is intended to support research that is conducted primarily in countries in which malaria is endemic, and must provide for significant involvement of local/regional researchers in study design, development, and execution.
Funding Opportunity PAR-23-030 from the NIH Guide for Grants and Contracts. The goal of the Leading Equity and Diversity in the Medical Scientist Training Program (LEAD MSTP) is to develop a diverse pool of highly trained clinician-scientist leaders available to meet the Nations biomedical research needs by providing support for dual-degree clinician scientist training at institutions that have historically not been well represented among NIGMS-funded MSTPs. Specifically, this Funding Opportunity Announcement (FOA) provides support to eligible domestic institutions to develop and implement effective, evidence-informed approaches to fully integrate the transitional phases of dual-degree training and mentoring that will lead to the completion of both clinical degrees (e.g., M.D., D.O., D.V.M., D.D.S., Pharm.D., etc.), and research doctorate degrees (Ph.D.) and keep pace with the rapid evolution of the biomedical enterprise. With the dual qualification of a rigorous scientist and clinician, graduates will be equipped with the skills to develop research programs that accelerate the translation of research advances to the understanding, detection, treatment, and prevention of human disease, and to lead the advancement of biomedical research. Areas of particular importance to NIGMS are optimizing training efficiency, fostering the persistence of alumni in research careers, and enhancing the diversity of the clinician-scientist workforce. NIGMS expects that the proposed research training programs will incorporate didactic, research, mentoring and career development elements to prepare trainees for careers that will have a significant impact on the health-related research needs of the Nation. This program is limited to dual-degree training programs at (1) Historically Black Colleges and Universities (HBCUs), (2) Tribal Colleges and Universities (TCUs), and (3) institutions in the states and territories that participate in the Institutional Development Award (IDeA) program, a congressionally mandated program that builds research capacity in state.
Notice NOT-OD-23-024 from the NIH Guide for Grants and Contracts
Notice NOT-CA-22-132 from the NIH Guide for Grants and Contracts
Notice NOT-GM-23-026 from the NIH Guide for Grants and Contracts
Funding Opportunity PAR-23-051 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement is to request applications that propose mechanistic investigations of the links between diet, lipid metabolism and tumor growth and progression. It is anticipated that this program will support fundamental studies designed to identify and define the molecular mechanisms through which lipid metabolism mediates tumor growth and progression, focusing specifically on the central role lipids play in linking diet with the biology of cancer; bridge the historically divided fields of nutrition and molecular metabolism; and stimulate research and tool development in this emerging area, which faces particular challenges because of the complexity of lipid biochemistry.
Funding Opportunity PAR-23-052 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement is to request applications that propose mechanistic investigations of the links between diet, lipid metabolism and tumor growth and progression. It is anticipated that this program will support fundamental studies designed to identify and define the molecular mechanisms through which lipid metabolism mediates tumor growth and progression, focusing specifically on the central role lipids play in linking diet with the biology of cancer; bridge the historically divided fields of nutrition and molecular metabolism; and stimulate research and tool development in this emerging area, which faces particular challenges because of the complexity of lipid biochemistry. For this announcement, unpublished preliminary data are limited to one figure, comprising no more than one-half page, to facilitate the entry of qualified new investigators to the field.
Funding Opportunity PAR-23-053 from the NIH Guide for Grants and Contracts. This FOA invites applications that propose to develop novel research infrastructure that will advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations. This FOA will use the NIH Phased Innovation Award (R61/R33) mechanism to provide up to 2 years of R61 support for initial developmental activities and up to 3 years of R33 support for expanded activities. Through this award, investigators will develop a sustainable research infrastructure to support projects that address key interdisciplinary aging research questions.
Funding Opportunity PAR-23-054 from the NIH Guide for Grants and Contracts. This FOA invites applications that propose to develop novel research infrastructure that will advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations.
Funding Opportunity PAR-23-025 from the NIH Guide for Grants and Contracts. Ancillary Studies to Ongoing Clinical Projects (R01 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-026 from the NIH Guide for Grants and Contracts. Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed)
Notice NOT-AR-23-004 from the NIH Guide for Grants and Contracts
Notice NOT-GM-23-010 from the NIH Guide for Grants and Contracts